Investigating the influence of KIBRA and CLSTN2 genetic polymorphisms on cross-sectional and longitudinal measures of memory performance and hippocampal volume in older individuals

Boraxbekk, C. J., Ames, David, Kochan, Nicole A., Lee, Teresa, Thalamuthu, Anbupalam, Wen, Wei, Armstrong, Nicola J., Kwok, John B. J., Schofield, Peter R., Reppermund, Simone, Wright, Margaret J., Trollor, Julian N., Brodaty, Henry, Sachdev, Perminder and Mather, Karen A. (2015) Investigating the influence of KIBRA and CLSTN2 genetic polymorphisms on cross-sectional and longitudinal measures of memory performance and hippocampal volume in older individuals. Neuropsychologia, 78 10-17. doi:10.1016/j.neuropsychologia.2015.09.031


Author Boraxbekk, C. J.
Ames, David
Kochan, Nicole A.
Lee, Teresa
Thalamuthu, Anbupalam
Wen, Wei
Armstrong, Nicola J.
Kwok, John B. J.
Schofield, Peter R.
Reppermund, Simone
Wright, Margaret J.
Trollor, Julian N.
Brodaty, Henry
Sachdev, Perminder
Mather, Karen A.
Title Investigating the influence of KIBRA and CLSTN2 genetic polymorphisms on cross-sectional and longitudinal measures of memory performance and hippocampal volume in older individuals
Journal name Neuropsychologia   Check publisher's open access policy
ISSN 1873-3514
0028-3932
Publication date 2015-11
Sub-type Article (original research)
DOI 10.1016/j.neuropsychologia.2015.09.031
Open Access Status Not Open Access
Volume 78
Start page 10
End page 17
Total pages 8
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon Press
Collection year 2015
Language eng
Formatted abstract
The variability of episodic memory decline and hippocampal atrophy observed with increasing age may partly be explained by genetic factors. KIBRA (kidney and brain expressed protein) and CLSTN2 (calsyntenin 2) are two candidate genes previously linked to episodic memory performance and volume of the hippocampus, a key memory structure. However, whether polymorphisms in these two genes also influence age-related longitudinal memory decline and hippocampal atrophy is still unknown. Using data from two independent cohorts, the Sydney Memory and Ageing Study and the Older Australian Twins Study, we investigated whether the KIBRA and CLSTN2 genetic polymorphisms (rs17070145 and rs6439886) are associated with episodic memory performance and hippocampal volume in older adults (65–90 years at baseline). We were able to examine these polymorphisms in relation to memory and hippocampal volume using cross-sectional data and, more importantly, also using longitudinal data (2 years between testing occasions). Overall we did not find support for an association of KIBRA either alone or in combination with CLSTN2 with memory performance or hippocampal volume, nor did variation in these genes influence longitudinal memory decline or hippocampal atrophy in two cohorts of older adults.
Keyword CLSTN2
Episodic memory
Gene-gene interactions
Hippocampus
KIBRA
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
Queensland Brain Institute Publications
School of Psychology Publications
 
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