Genotype by environment interactions in cognitive ability: a survey of 14 studies from four countries covering four age groups

Molenaar, Dylan, van der Sluis, Sophie, Boomsma, Dorret I., Haworth, Claire M. A., Hewitt, John K., Martin, Nicholas G., Plomin, Robert, Wright, Margaret J. and Dolan, Conor V. (2013) Genotype by environment interactions in cognitive ability: a survey of 14 studies from four countries covering four age groups. Behavior Genetics, 43 3: 208-219. doi:10.1007/s10519-012-9581-7


Author Molenaar, Dylan
van der Sluis, Sophie
Boomsma, Dorret I.
Haworth, Claire M. A.
Hewitt, John K.
Martin, Nicholas G.
Plomin, Robert
Wright, Margaret J.
Dolan, Conor V.
Title Genotype by environment interactions in cognitive ability: a survey of 14 studies from four countries covering four age groups
Journal name Behavior Genetics   Check publisher's open access policy
ISSN 0001-8244
1573-3297
Publication date 2013-05
Sub-type Article (original research)
DOI 10.1007/s10519-012-9581-7
Open Access Status Not yet assessed
Volume 43
Issue 3
Start page 208
End page 219
Total pages 12
Place of publication New York, NY United States
Publisher Springer New York
Language eng
Abstract A large part of the variation in cognitive ability is known to be due to genetic factors. Researchers have tried to identify modifiers that influence the heritability of cognitive ability, indicating a genotype by environment interaction (G×E). To date, such modifiers include measured variables like income and socioeconomic status. The present paper focuses on G×E in cognitive ability where the environmental variable is an unmeasured environmental factor that is uncorrelated in family members. We examined this type of G×E in the GHCA-database (Haworth et al., Behav Genet 39:359-370, 2009), which comprises data of 14 different cognition studies from four different countries including participants of different ages. Results indicate that for younger participants (4-13 years), the strength of E decreases across the additive genetic factor A, but that this effect reverts for older participants (17-34 years). However, a clear and general conclusion about the presence of a genuine G×E is hampered by differences between the individual studies with respect to environmental and genetic influences on cognitive ability.
Keyword Genotype by environment interaction
Heritability
Environment
Intelligence
Development
Ability differentiation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
 
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