A genomewide scan for intelligence identifies quantitative trait loci on 2q and 6p

Posthuma, Danielle, Luciano, Michelle, de Geus, Eco J. C., Wright, Margie J., Slagboom, P. Eline, Montgomery, Grant W., Boomsma, Dorret I. and Martin, Nicholas G. (2005) A genomewide scan for intelligence identifies quantitative trait loci on 2q and 6p. American Journal of Human Genetics, 77 2: 318-326. doi:10.1086/432647


Author Posthuma, Danielle
Luciano, Michelle
de Geus, Eco J. C.
Wright, Margie J.
Slagboom, P. Eline
Montgomery, Grant W.
Boomsma, Dorret I.
Martin, Nicholas G.
Title A genomewide scan for intelligence identifies quantitative trait loci on 2q and 6p
Journal name American Journal of Human Genetics   Check publisher's open access policy
ISSN 0002-9297
1537-6605
Publication date 2005-08
Sub-type Article (original research)
DOI 10.1086/432647
Open Access Status Not yet assessed
Volume 77
Issue 2
Start page 318
End page 326
Total pages 9
Place of publication Cambridge, MA, United States
Publisher Cell Press
Language eng
Abstract Between 40% and 80% of the variation in human intelligence (IQ) is attributable to genetic factors. Except for many rare mutations resulting in severe cognitive dysfunction, attempts to identify these factors have not been successful. We report a genomewide linkage scan involving 634 sibling pairs designed to identify chromosomal regions that explain variation in IQ. Model-free multipoint linkage analysis revealed evidence of a significant quantitative-trait locus for performance IQ at 2q24.1-31.1 (LOD score 4.42), which overlaps the 2q21-33 region that has repeatedly shown linkage to autism. A second region revealed suggestive linkage for both full-scale and verbal IQs on 6p25.3-22.3 (LOD score 3.20 for full-scale IQ and 2.33 for verbal IQ), overlapping marginally with the 6p22.3-21.31 region implicated in reading disability and dyslexia.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Institute for Molecular Bioscience - Publications
 
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