A genome-wide study on the perception of the odorants androstenone and galaxolide

Knaapila, Antti, Zhu, Gu, Medland, Sarah E., Wysocki, Charles J., Montgomery, Grant W., Martin, Nicholas G., Wright, Margaret J. and Reed, Danielle R. (2012) A genome-wide study on the perception of the odorants androstenone and galaxolide. Chemical Senses, 37 6: 541-552. doi:10.1093/chemse/bjs008

Author Knaapila, Antti
Zhu, Gu
Medland, Sarah E.
Wysocki, Charles J.
Montgomery, Grant W.
Martin, Nicholas G.
Wright, Margaret J.
Reed, Danielle R.
Title A genome-wide study on the perception of the odorants androstenone and galaxolide
Journal name Chemical Senses   Check publisher's open access policy
ISSN 0379-864X
Publication date 2012
Sub-type Article (original research)
DOI 10.1093/chemse/bjs008
Open Access Status Not yet assessed
Volume 37
Issue 6
Start page 541
End page 552
Total pages 12
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Language eng
Formatted abstract
Twin pairs and their siblings rated the intensity of the odorants amyl acetate, androstenone, eugenol, Galaxolide, mercaptans, and rose (N = 1573). Heritability was established for ratings of androstenone (h2 = 0.30) and Galaxolide (h2 = 0.34) but not for the other odorants. Genome-wide association analysis using 2.3 million single nucleotide polymorphisms indicated that the most significant association was between androstenone and a region without known olfactory receptor genes (rs10966900, P = 1.2 × 10-7). A previously reported association between the olfactory receptor OR7D4 and the androstenone was not detected until we specifically typed this gene (P = 1.1 × 10-4). We also tested these 2 associations in a second independent sample of subjects and replicated the results either fully (OR7D4, P = 0.00002) or partially (rs10966900, P = 0.010; N = 266). These findings suggest that 1) the perceived intensity of some but not all odorants is a heritable trait, 2) use of a current genome-wide marker panel did not detect a known olfactory genotype-phenotype association, and 3) person-to-person differences in androstenone perception are influenced by OR7D4 genotype and perhaps by variants of other genes.
Keyword Androstenone
Genetic twin modeling
Genome-wide association study
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 12 times in Thomson Reuters Web of Science Article | Citations
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