Bioavailability study of arsenic and mercury in traditional Chinese medicines (TCM) using an animal model after a single dose exposure

Tinggi, Ujang, Sadler, Ross, Ng, Jack, Noller, Barry and Seawright, Alan (2016) Bioavailability study of arsenic and mercury in traditional Chinese medicines (TCM) using an animal model after a single dose exposure. Regulatory Toxicology and Pharmacology, 76 51-56. doi:10.1016/j.yrtph.2016.01.010

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads

Author Tinggi, Ujang
Sadler, Ross
Ng, Jack
Noller, Barry
Seawright, Alan
Title Bioavailability study of arsenic and mercury in traditional Chinese medicines (TCM) using an animal model after a single dose exposure
Journal name Regulatory Toxicology and Pharmacology   Check publisher's open access policy
ISSN 1096-0295
0273-2300
Publication date 2016-04-01
Sub-type Article (original research)
DOI 10.1016/j.yrtph.2016.01.010
Open Access Status File (Author Post-print)
Volume 76
Start page 51
End page 56
Total pages 6
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Collection year 2017
Language eng
Formatted abstract
Traditional Chinese medicines (TCM) are increasingly being used as alternative medicines in many countries, and this has caused concern because of adverse health effects from toxic metal bioavailability such as mercury (Hg) and arsenic (As). The aim of this study was to investigate the bioavailability of As and Hg from TCM after a single exposure dose using an animal model of female Sprague–Dawley rats. The rats were divided into 6 groups which included four groups treated with sodium arsenite (NaAsO2), arsenic sulfide (As2S3), mercuric chloride (HgCl2), mercuric sulfide (HgS), and two groups treated with TCM containing high Hg or As (Liu Shen Wan: As 7.7–9.1% and Hg 1.4–5.0%; Niuhang Jie du Pian: As 6.2–7.9% and Hg <0.001%). The samples of urine, faeces, kidney and liver were collected for analysis and histological assay. The results indicated that relatively low levels of As and Hg from these TCM were retained in liver and kidney tissues. The levels of As in these tissues after TCM treatment were consistent with the levels from the As sulphide treated group. With the exception of the mercuric chloride treated group, the levels of Hg in urine from other groups were very low, and high levels of As and Hg from TCM were excreted in faeces. The study showed poor bioavailability of As and Hg from TCM as indicated by low relative bioavailability of As (0.60–1.10%) and Hg (<0.001%). Histopathological examination of rat kidney and liver tissues did not show toxic effects from TCM.
Keyword Chinese medicines
Rat study
Relative bioavailability
Risk assessment
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 2 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 3 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 09 Feb 2016, 10:14:37 EST by System User on behalf of Learning and Research Services (UQ Library)