IK1 channels do not contribute to the slow after hyperpolarization in pyramidal neurons

Wang, Kang, Mateos-Aparicio, Pedro, Honigsperger, Christoph, Raghuram, Vijeta, Wu, Wendy W., Ridder, Margreet C., Sah, Pankaj, Mayile, Jim, Storm, Johan F. and Adelman, John P. (2016) IK1 channels do not contribute to the slow after hyperpolarization in pyramidal neurons. eLife, 5 e11206: 1-16. doi:10.7554/eLife.11206

Author Wang, Kang
Mateos-Aparicio, Pedro
Honigsperger, Christoph
Raghuram, Vijeta
Wu, Wendy W.
Ridder, Margreet C.
Sah, Pankaj
Mayile, Jim
Storm, Johan F.
Adelman, John P.
Title IK1 channels do not contribute to the slow after hyperpolarization in pyramidal neurons
Journal name eLife   Check publisher's open access policy
ISSN 2050-084X
Publication date 2016-01-14
Year available 2016
Sub-type Article (original research)
DOI 10.7554/eLife.11206
Open Access Status DOI
Volume 5
Issue e11206
Start page 1
End page 16
Total pages 16
Place of publication Cambridge, United Kingdom
Publisher eLife Sciences Publications
Collection year 2017
Language eng
Formatted abstract
In pyramidal neurons such as hippocampal area CA1 and basolateral amygdala, a slow afterhyperpolarization (sAHP) follows a burst of action potentials, which is a powerful regulator of neuronal excitability. The sAHP amplitude increases with aging and may underlie age related memory decline. The sAHP is due to a Ca2+-dependent, voltage-independent K+ conductance, the molecular identity of which has remained elusive until a recent report suggested the Ca2+-activated K+ channel, IK1 (KCNN4) as the sAHP channel in CA1 pyramidal neurons. The signature pharmacology of IK1, blockade by TRAM-34, was reported for the sAHP and underlying current. We have examined the sAHP and find no evidence that TRAM-34 affects either the current underling the sAHP or excitability of CA1 or basolateral amygdala pyramidal neurons. In addition, CA1 pyramidal neurons from IK1 null mice exhibit a characteristic sAHP current. Our results indicate that IK1 channels do not mediate the sAHP in pyramidal neurons.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
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