Betel-quid chewing with or without tobacco is a major risk factor for oral potentially malignant disorders in Sri Lanka: a case-control study

Amarasinghe, Hemantha K., Usgodaarachchi, Udaya S., Johnson, Newell W., Lalloo, Ratilal and Warnakulasuriya, Saman (2010) Betel-quid chewing with or without tobacco is a major risk factor for oral potentially malignant disorders in Sri Lanka: a case-control study. Oral Oncology, 46 4: 297-301. doi:10.1016/j.oraloncology.2010.01.017


Author Amarasinghe, Hemantha K.
Usgodaarachchi, Udaya S.
Johnson, Newell W.
Lalloo, Ratilal
Warnakulasuriya, Saman
Title Betel-quid chewing with or without tobacco is a major risk factor for oral potentially malignant disorders in Sri Lanka: a case-control study
Journal name Oral Oncology   Check publisher's open access policy
ISSN 1368-8375
1879-0593
Publication date 2010-04
Sub-type Article (original research)
DOI 10.1016/j.oraloncology.2010.01.017
Open Access Status Not yet assessed
Volume 46
Issue 4
Start page 297
End page 301
Total pages 5
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon Press
Language eng
Abstract We investigated the prevalence of, and risk factors for, oral potentially malignant disorders (OPMDs) in rural Sri Lanka. A cross-sectional community-based study was conducted by interview and oral examination of 1029 subjects aged over 30 years. A community-based nested case-control study then took those with OPMDs as 'cases', "controls" being those with no oral abnormalities at time of initial screening. The prevalence of OPMD was 11.3% (95% CI: 9.4-13.2), after weighting for place of residence and gender. Risk factors were betel-quid (BQ) chewing daily [OR = 10.6 (95% CI: 3.6-31.0)] and alcohol drinking daily or weekly [OR = 3.55 (1.6-8.0)]. A significant dose-response relationship existed for BQ chewing. Smoking did not emerge when adjusted for covariates. A synergistic effect of chewing and alcohol consumption existed. The attributable risk (AR) of daily BQ chewing was 90.6%, the population AR 84%. This study demonstrates high prevalence of OPMD, betel-quid chewing with or without tobacco being the major risk factor.
Keyword Alcohol
Betel-quid
Oral cancer, oral potentially malignant disorders
Oral leukoplakia
Oral submucous fibrosis
Risk factors
Sri Lanka
Tobacco
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Dentistry Publications
 
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