The binding of an indefinitely associating ligand to acceptor: Consideration of monovalent ligand species binding to a multivalent acceptor

Mark, AE, Jeffrey, PD and Nichol, LW (1988) The binding of an indefinitely associating ligand to acceptor: Consideration of monovalent ligand species binding to a multivalent acceptor. Journal of Theoretical Biology, 131 2: 137-149. doi:10.1016/S0022-5193(88)80231-5


Author Mark, AE
Jeffrey, PD
Nichol, LW
Title The binding of an indefinitely associating ligand to acceptor: Consideration of monovalent ligand species binding to a multivalent acceptor
Journal name Journal of Theoretical Biology   Check publisher's open access policy
ISSN 1095-8541
Publication date 1988-03-21
Sub-type Article (original research)
DOI 10.1016/S0022-5193(88)80231-5
Volume 131
Issue 2
Start page 137
End page 149
Total pages 13
Language eng
Subject 1100 Agricultural and Biological Sciences
1300 Biochemistry, Genetics and Molecular Biology
2400 Immunology and Microbiology
2604 Applied Mathematics
2611 Modelling and Simulation
2613 Statistics and Probability
2700 Medicine
Abstract Currently available binding theory is extended to incorporate the concept of indefinite self-association of the ligand. Binding equations are formulated in closed form for the case of the binding to a multivalent acceptor of a ligand capable of isodesmically indefinitely self-associating in a "head-to-tail" mode such that each ligand state bears one site capable of interacting with the acceptor. It is shown both mathematically and by way of numerical example that this system will give rise exclusively to binding curves convex to the r-axis in Scatchard format. Thus, the system provides another example of a binding mechanism capable of generating an apparent negatively co-operative binding response.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: ResearcherID Downloads
Scopus Import
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 5 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 5 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 03 Feb 2016, 15:01:02 EST by System User