The clinical research enterprise in critical care: what's right, what's wrong, and what's ahead?

Reade, Michael C. and Angus, Derek C. (2009) The clinical research enterprise in critical care: what's right, what's wrong, and what's ahead?. Critical Care Medicine, 37 S1: S1-S9. doi:10.1097/CCM.0b013e318192074c


Author Reade, Michael C.
Angus, Derek C.
Title The clinical research enterprise in critical care: what's right, what's wrong, and what's ahead?
Journal name Critical Care Medicine   Check publisher's open access policy
ISSN 0090-3493
1530-0293
Publication date 2009-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1097/CCM.0b013e318192074c
Open Access Status Not yet assessed
Volume 37
Issue S1
Start page S1
End page S9
Total pages 9
Place of publication Philadelphia, PA, United States
Publisher Lippincott Williams & Wilkins
Language eng
Abstract Intensivists have been remarkably successful in using randomized controlled trials to assess aspects of current practice. Unfortunately, this success has not been mirrored in trials of new pharmacotherapy, despite convincing pathophysiological rationales and encouraging preliminary studies. Misunderstandings of biological processes and flawed early clinical studies have led to the almost universal failure of fundamentally new treatments subjected to large phase III trials, despite their sound methodology. Compounding these problems is the tendency for new approaches to be either implemented widely on the basis of relatively poor studies or ignored despite strong supporting evidence. Having mastered the principles of evidence-based medicine in assessing existing therapy, intensivists have established a strong foundation. Critical care medicine must now embrace the challenge of translating a more solid understanding of basic disease mechanisms into widely implemented treatments.
Keyword Clinical trials
Intensive care
Phase II
Phase III
Priority
Research
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
 
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