Mouse models of tumor immunotherapy

Ngiow, Shin Foong, Loi, Sherene, Thomas, David and Smyth, Mark J. (2016) Mouse models of tumor immunotherapy. Advances in Immunology, 130 1-24. doi:10.1016/

Author Ngiow, Shin Foong
Loi, Sherene
Thomas, David
Smyth, Mark J.
Title Mouse models of tumor immunotherapy
Journal name Advances in Immunology   Check publisher's open access policy
ISSN 1557-8445
ISBN 978-0-12-805156-6
Publication date 2016
Sub-type Article (original research)
DOI 10.1016/
Open Access Status Not Open Access
Volume 130
Start page 1
End page 24
Total pages 24
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Collection year 2017
Language eng
Abstract Immunotherapy is now evolving into a major therapeutic option for cancer patients. Such clinical advances also promote massive interest in the search for novel immunotherapy targets, and to understand the mechanism of action of current drugs. It is projected that a series of novel immunotherapy agents will be developed and assessed for their therapeutic activity. In light of this, in vivo experimental mouse models that recapitulate human malignancies serve as valuable tools to validate the efficacy and safety profile of immunotherapy agents, before their transition into clinical trials. In this review, we will discuss the major classes of experimental mouse models of cancer commonly used for immunotherapy assessment and provide examples to guide the selection of appropriate models. We present some new data concerning the utility of a carcinogen-induced tumor model for comparing immunotherapies and combining immunotherapy with chemotherapy. We will also highlight some recent advances in experimental modeling of human malignancies in mice that are leading towards personalized therapy in patients.
Keyword Carcinogen
Mouse tumor models
T cell
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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