Is pulmonary non-tuberculous mycobacterial disease linked with a high burden of latent cytomegalovirus?

Amran, Fathiah S., Kim, Kyungchul, Lim, Andrew, Thomson, Rachel, Lee, Silvia, Waterer, Grant and Price, Patricia (2016) Is pulmonary non-tuberculous mycobacterial disease linked with a high burden of latent cytomegalovirus?. Journal of Clinical Immunology, 36 2: 113-116. doi:10.1007/s10875-016-0233-1


Author Amran, Fathiah S.
Kim, Kyungchul
Lim, Andrew
Thomson, Rachel
Lee, Silvia
Waterer, Grant
Price, Patricia
Title Is pulmonary non-tuberculous mycobacterial disease linked with a high burden of latent cytomegalovirus?
Journal name Journal of Clinical Immunology   Check publisher's open access policy
ISSN 1573-2592
0271-9142
Publication date 2016-01-13
Year available 2016
Sub-type Article (original research)
DOI 10.1007/s10875-016-0233-1
Open Access Status Not Open Access
Volume 36
Issue 2
Start page 113
End page 116
Total pages 4
Place of publication New York, NY, United States
Publisher Springer New York LLC
Collection year 2017
Language eng
Abstract Cytomegalovirus (CMV) establishes lifelong infections with episodes of active replication. We hypothesized that recurrent CMV replication in older individuals may suppress protective immune responses to non-tuberculous mycobacteria (NTM) and so potentiate pulmonary disease. Accordingly, levels of antibodies to three CMV antigen preparations were higher in NTM patients than in age-matched controls. This did not reflect broad-spectrum B cell activation as total immunoglobulin levels were not equivalently increased.
Keyword Cytomegalovirus
Immunosuppression
Non-tuberculous mycobacteria
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Admin Only - School of Medicine
School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in Thomson Reuters Web of Science Article
Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Tue, 02 Feb 2016, 00:36:58 EST by System User on behalf of Learning and Research Services (UQ Library)