Synthesis of mannose-cholesterol conjugates for targeted liposomal drug delivery

Nguyen, Huong, Katavic, Peter, Bashah, Nur Atikah Halim and Ferro, Vito (2016) Synthesis of mannose-cholesterol conjugates for targeted liposomal drug delivery. ChemistrySelect, 1 1: 31-35. doi:10.1002/slct.201600007


Author Nguyen, Huong
Katavic, Peter
Bashah, Nur Atikah Halim
Ferro, Vito
Title Synthesis of mannose-cholesterol conjugates for targeted liposomal drug delivery
Journal name ChemistrySelect   Check publisher's open access policy
ISSN 2365-6549
Publication date 2016-01
Sub-type Article (original research)
DOI 10.1002/slct.201600007
Open Access Status Not Open Access
Volume 1
Issue 1
Start page 31
End page 35
Total pages 5
Place of publication Weinheim, Germany
Publisher Wiley - V C H Verlag
Collection year 2017
Language eng
Abstract Several novel, mannose-cholesterol conjugates for use in targeted liposomal drug delivery were synthesized via a modular strategy utilizing the Cu(I)-catalysed Huisgen azide-alkyne cycloaddition (“Click”) reaction. The conjugates, which were fully characterized, comprised either a single mannose unit or a trivalent mannose cluster joined to cholesterol via bifunctional PEG-based linkers of different lengths. The neutral conjugates offer advantages over a previously reported cationic conjugate and the modular strategy employed can be readily adapted for the preparation of conjugates with alternative targeting groups.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Chemistry and Molecular Biosciences
 
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Created: Fri, 22 Jan 2016, 09:47:35 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences