Discovery and characterisation of a new insect-specific bunyavirus from Culex mosquitoes captured in northern Australia

Hobson-Peters, Jody, Warrilow, David, McLean, Breeanna J., Watterson, Daniel, Colmant, Agathe M.G., van den Hurk, Andrew F., Hall-Mendelin, Sonja, Hastie, Marcus L., Gorman, Jeffrey J., Harrison, Jessica J., Prow, Natalie A., Barnard, Ross T., Allcock, Richard, Johansen, Cheryl A. and Hall, Roy A. (2016) Discovery and characterisation of a new insect-specific bunyavirus from Culex mosquitoes captured in northern Australia. Virology, 489 269-281. doi:10.1016/j.virol.2015.11.003


Author Hobson-Peters, Jody
Warrilow, David
McLean, Breeanna J.
Watterson, Daniel
Colmant, Agathe M.G.
van den Hurk, Andrew F.
Hall-Mendelin, Sonja
Hastie, Marcus L.
Gorman, Jeffrey J.
Harrison, Jessica J.
Prow, Natalie A.
Barnard, Ross T.
Allcock, Richard
Johansen, Cheryl A.
Hall, Roy A.
Title Discovery and characterisation of a new insect-specific bunyavirus from Culex mosquitoes captured in northern Australia
Formatted title
Discovery and characterisation of a new insect-specific bunyavirus from Culex mosquitoes captured in northern Australia
Journal name Virology   Check publisher's open access policy
ISSN 0042-6822
1096-0341
Publication date 2016-02
Sub-type Article (original research)
DOI 10.1016/j.virol.2015.11.003
Open Access Status Not Open Access
Volume 489
Start page 269
End page 281
Total pages 13
Place of publication Waltham, United States
Publisher Academic Press
Collection year 2017
Language eng
Formatted abstract
Insect-specific viruses belonging to significant arboviral families have recently been discovered. These viruses appear to be maintained within the insect population without the requirement for replication in a vertebrate host. Mosquitoes collected from Badu Island in the Torres Strait in 2003 were analysed for insect-specific viruses. A novel bunyavirus was isolated in high prevalence from Culex spp. The new virus, provisionally called Badu virus (BADUV), replicated in mosquito cells of both Culex and Aedes origin, but failed to replicate in vertebrate cells. Genomic sequencing revealed that the virus was distinct from sequenced bunyavirus isolates reported to date, but phylogenetically clustered most closely with recently discovered mosquito-borne, insect-specific bunyaviruses in the newly proposed Goukovirus genus. The detection of a functional furin cleavage motif upstream of the two glycoproteins in the M segment-encoded polyprotein suggests that BADUV may employ a unique strategy to process the virion glycoproteins.
Keyword Bunyavirus
Goukovirus
Insect-specific
Mosquito
Mosquito-specific
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Chemistry and Molecular Biosciences
 
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Created: Fri, 22 Jan 2016, 09:39:20 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences