Investigation of polycaprolactone matrices for intravaginal delivery of doxycycline

Pathak, Meenakshi, Coombes, Allan G. A., Turner, Mark S., Palmer, Cheryn, Wang, Dongjie and Steadman, Kathryn J. (2015) Investigation of polycaprolactone matrices for intravaginal delivery of doxycycline. Journal of Pharmaceutical Sciences, 104 12: 4217-4222. doi:10.1002/jps.24652


Author Pathak, Meenakshi
Coombes, Allan G. A.
Turner, Mark S.
Palmer, Cheryn
Wang, Dongjie
Steadman, Kathryn J.
Title Investigation of polycaprolactone matrices for intravaginal delivery of doxycycline
Journal name Journal of Pharmaceutical Sciences   Check publisher's open access policy
ISSN 0022-3549
1520-6017
Publication date 2015-12
Sub-type Article (original research)
DOI 10.1002/jps.24652
Open Access Status Not Open Access
Volume 104
Issue 12
Start page 4217
End page 4222
Total pages 6
Place of publication New York, United States
Publisher Elsevier
Collection year 2016
Language eng
Formatted abstract
Polycaprolactone (PCL) matrices loaded with doxycycline were produced by rapidly cooling suspensions of the drug powder in PCL solution in acetone. Drug loadings of 5%, 10%, and 15% (w/w) of the PCL content were achieved. Exposure of doxycycline powder to matrix processing conditions in the absence of PCL revealed an endothermic peak at 65 °C with the main peak at 167 °C, suggesting solvatomorph formation. Rapid “burst release” of 24%–32% was measured within 24 h when matrices were immersed in simulated vaginal fluid (SVF) at 37 °C, because of the presence of drug at or close to the matrix surface, which is further confirmed by scanning electron microscopy. Gradual release of 66%–76% of the drug content occurred over the following 14 days. SVF containing doxycycline released from drug-loaded PCL matrices retained 81%–90% antimicrobial activity compared with the nonformulated drug. The concentrations of doxycycline predicted to be released into vaginal fluid from a PCL matrix in the form of an intravaginal ring would be sufficient to kill Neisseria gonorrhoea and many other pathogens. These results indicate that PCL may be a suitable polymer for controlled intravaginal delivery of doxycycline for the treatment of sexually transmitted infections.
Keyword Differential scanning calorimetry (DSC)
Controlled delivery
Crystallinity
Drug delivery systems
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
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Created: Thu, 21 Jan 2016, 16:53:42 EST by Ms Felicity Lindberg on behalf of School of Pharmacy