Association of the microRNA-Single Nucleotide Polymorphism rs2910164 in miR146a with sporadic breast cancer susceptibility: A case control study

Upadhyaya, Akanksha, Smith, Robert A., Chacon-Cortes, Diego, Revechon, Gwladys, Bellis, Claire, Lea, Rod A., Haupt, Larisa M., Chambers, Suzanne K., Youl, Philippa H. and Griffiths, Lyn R. (2016) Association of the microRNA-Single Nucleotide Polymorphism rs2910164 in miR146a with sporadic breast cancer susceptibility: A case control study. Gene, 576 1, Part 2: 256-260. doi:10.1016/j.gene.2015.10.019


Author Upadhyaya, Akanksha
Smith, Robert A.
Chacon-Cortes, Diego
Revechon, Gwladys
Bellis, Claire
Lea, Rod A.
Haupt, Larisa M.
Chambers, Suzanne K.
Youl, Philippa H.
Griffiths, Lyn R.
Title Association of the microRNA-Single Nucleotide Polymorphism rs2910164 in miR146a with sporadic breast cancer susceptibility: A case control study
Journal name Gene   Check publisher's open access policy
ISSN 1879-0038
0378-1119
Publication date 2016-01-15
Year available 2015
Sub-type Article (original research)
DOI 10.1016/j.gene.2015.10.019
Open Access Status Not yet assessed
Volume 576
Issue 1, Part 2
Start page 256
End page 260
Total pages 5
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2016
Language eng
Formatted abstract
Background: Breast cancer (BC) is primarily considered a genetic disorder with a complex interplay of factors including age, gender, ethnicity, family history, personal history and lifestyle with associated hormonal and non-hormonal risk factors. The SNP rs2910164 in miR146a (a G to C polymorphism) was previously associated with increased risk of BC in cases with at least a single copy of the C allele in breast cancer, though results in other cancers and populations have shown significant variation.

Methods: 
In this study, we examined this SNP in an Australian sporadic breast cancer population of 160 cases and matched controls, with a replicate population of 403 breast cancer cases using High Resolution Melting.

Results: Our analysis indicated that the rs2910164 polymorphism is associated with breast cancer risk in both primary and replicate populations (p = 0.03 and 0.0013, respectively). In contrast to the results of familial breast cancer studies, however, we found that the presence of the G allele of rs2910164 is associated with increased cancer risk, with an OR of 1.77 (95% CI 1.40–2.23).

Conclusions: 
The microRNA miR146a has a potential role in the development of breast cancer and the effects of its SNPs require further inquiry to determine the nature of their influence on breast tissue and cancer.
Keyword MiR146a
Polymorphism
Breast cancer
BRCA
SNP
MiRNA
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2016 Collection
 
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