Transthoracic ventricular fibrillation charge thresholds

Panescu, Dorin, Kroll, Mark, Andrews, Chris and Pratt, Hugh (2015). Transthoracic ventricular fibrillation charge thresholds. In: 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015. 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015, Milan, Italy, (7208-7213). 25-29 August, 2015. doi:10.1109/EMBC.2015.7320055


Author Panescu, Dorin
Kroll, Mark
Andrews, Chris
Pratt, Hugh
Title of paper Transthoracic ventricular fibrillation charge thresholds
Conference name 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015
Conference location Milan, Italy
Conference dates 25-29 August, 2015
Convener IEEE
Proceedings title 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015   Check publisher's open access policy
Journal name Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS   Check publisher's open access policy
Series Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Place of Publication Piscataway, NJ, United States
Publisher Institute of Electrical and Electronics Engineers
Publication Year 2015
Sub-type Fully published paper
DOI 10.1109/EMBC.2015.7320055
Open Access Status Not Open Access
ISBN 9781424492718
ISSN 1557-170X
Volume 2015-November
Start page 7208
End page 7213
Total pages 6
Collection year 2016
Language eng
Abstract/Summary Standards, including IEC 60479-1 and -2, provide current-based ventricular fibrillation thresholds (VFT) for stimuli durations between 0.1 ms and 10 s. It has been established that the amount of electrical charge, not the current calculated by root-mean-square, is most representative of the effects of cardiac stimulation. There are no unified models that present transthoracic charge VFTs for a wide range of stimuli durations. This work proposes a new unified charge model applicable to transthoracic stimuli durations ranging over 1 μs - 300 s. VFTs were compiled from our previous animal work and from other published reports, including from the studies that provided the raw data for IEC 60479-1 and -2. Our study goal was to cover a wide range of stimuli durations, for which reliable data exists. Consistent data were found for stimuli durations covering the range of 1 μs - 300 s where VFTs were expressed as charge. The model predicted a transthoracic charge VFT of 1 mC at 1 μs duration. The charge VFT increased with stimulus duration and reached 10 C at 300 s. Presenting the first charge-based transthoracic VFT model covering stimuli durations over 1 μs - 300 s, we found 3 behavioral regions of charge VFT vs. duration. For short stimuli durations, 1 μs - 10 ms, VFTs followed a classic Weiss charge strength-duration curve. For long stimuli, longer than 5 s, charge VFTs can be approximated using a 38 mArms constant current model. From 10 ms to 5 s, charge VFTs tracked through a transition zone that could be approximated as a constant charge model Q≈100 mC.
Keyword Charge
Electrophysiology
Stimulation
Ventricular Fibrillation
Q-Index Code E1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Conference Paper
Collections: Official 2016 Collection
School of Medicine Publications
 
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