Epidemiology of biopsy-proven glomerulonephritis in Queensland adults

Jegatheesan, Dev, Nath, Karthik, Reyaldeen, Reza, Sivasuthan, Goutham, John, George T., Francis, Leo, Rajmokan, Mohana and Ranganathan, Dwarakanathan (2016) Epidemiology of biopsy-proven glomerulonephritis in Queensland adults. Nephrology, 21 1: 28-34. doi:10.1111/nep.12559


Author Jegatheesan, Dev
Nath, Karthik
Reyaldeen, Reza
Sivasuthan, Goutham
John, George T.
Francis, Leo
Rajmokan, Mohana
Ranganathan, Dwarakanathan
Title Epidemiology of biopsy-proven glomerulonephritis in Queensland adults
Journal name Nephrology   Check publisher's open access policy
ISSN 1440-1797
1320-5358
Publication date 2016-01-01
Year available 2016
Sub-type Article (original research)
DOI 10.1111/nep.12559
Open Access Status Not Open Access
Volume 21
Issue 1
Start page 28
End page 34
Total pages 7
Place of publication Richmond, VIC Australia
Publisher Wiley-Blackwell Publishing Asia
Collection year 2017
Language eng
Subject 2727 Nephrology
Formatted abstract
Aim
There is a paucity of data pertaining to the incidence of biopsy-proven glomerulonephritis (GN) in Australia. This retrospective study aims to review the data from all adult native renal biopsies performed in the state of Queensland from 2002 to 2011 – comparing results with centres from across the world.

Methods
Pathology reports of 3697 adult native kidney biopsies were reviewed, of which 2048 had GN diagnoses. Age, gender, clinical indication and histopathology findings were compared.

Results
The average age at biopsy was 48 ± 17 years. Male preponderance was noted overall (∼60%), with lupus nephritis being the only individual GN with female predilection. The average rate of biopsy was 12.04 per hundred thousand people per year (php/yr). Nephrotic and nephritic syndromes comprised approximately 75% of all clinical indications that lead to GN diagnoses. IgA nephropathy (1.41 php/yr) was the most common primary GN followed by focal segmental glomerulosclerosis (1.02 php/yr) and crescentic GN (0.73 php/yr). Diabetic nephropathy (0.84 php/yr), lupus nephritis (0.69 php/yr) and amyloidosis (0.19 php/yr) were the most commonly identified secondary GN.

Conclusion
IgA nephropathy is the predominant primary GN in Queensland, and nephrotic syndrome the most common indication for a renal biopsy. While crescentic GN incidence has significantly increased with time, focal segmental glomerulosclerosis incidence has not shown any trend. Incidence of GN overall appears to increase with age. The annual rate of biopsy in this study appears lower than previously published in an Australian population.
Keyword Australia
Epidemiology
Glomerulonephritis
Nephritic
Queensland
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

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Sub-type: Article (original research)
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