The impact on health-related quality of life in the first 12 months: a randomised comparison of preoperative short-course radiation versus long-course chemoradiation for T3 rectal cancer (Trans-Tasman Radiation Oncology Group Trial 01.04)

McLachlan, Sue-Anne, Fisher, Richard J., Zalcberg, John, Solomon, Michael, Burmeister, Bryan, Goldstein, David, Leong, Trevor, Ackland, Stephen P., McKendrick, Joseph, McClure, Bev, MacKay, John and Ngan, Samuel Y. (2016) The impact on health-related quality of life in the first 12 months: a randomised comparison of preoperative short-course radiation versus long-course chemoradiation for T3 rectal cancer (Trans-Tasman Radiation Oncology Group Trial 01.04). European Journal of Cancer, 55 15-26. doi:10.1016/j.ejca.2015.10.060


Author McLachlan, Sue-Anne
Fisher, Richard J.
Zalcberg, John
Solomon, Michael
Burmeister, Bryan
Goldstein, David
Leong, Trevor
Ackland, Stephen P.
McKendrick, Joseph
McClure, Bev
MacKay, John
Ngan, Samuel Y.
Title The impact on health-related quality of life in the first 12 months: a randomised comparison of preoperative short-course radiation versus long-course chemoradiation for T3 rectal cancer (Trans-Tasman Radiation Oncology Group Trial 01.04)
Journal name European Journal of Cancer   Check publisher's open access policy
ISSN 1879-0852
0959-8049
Publication date 2016-03
Sub-type Article (original research)
DOI 10.1016/j.ejca.2015.10.060
Open Access Status Not Open Access
Volume 55
Start page 15
End page 26
Total pages 12
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon Press
Collection year 2017
Language eng
Formatted abstract
Purpose: To assess health-related quality of life (HRQOL) in patients participating in a randomised trial of neoadjuvant short course radiation (SC) or long course chemoradiation (LC) for operable rectal cancer.
Patients and methods: Eligible patients with T3N0-2M0 rectal cancer completed the European Organisation for Research and Treatment of Cancer quality of life questionnaire (QLQ-C30) and the colorectal cancer specific module (QLQ C38) at randomisation and 1, 2, 3, 6, 9 and 12 months later.
Results: Of 326 patients randomised, 297 (SC 143, LC 154) were eligible for completion of HRQOL questionnaires. Baseline scores were comparable across the SC and LC groups. Patients reported low scores on sexual functioning and sexual enjoyment. Defaecation problems were the worst of the symptoms at baseline. Surgery had the most profoundly negative effect on HRQOL, seen in both the SC and LC treatment groups to the same extent. The most severely affected domains were physical function and role function and the most severely affected symptoms were fatigue, pain, appetite, weight loss and male sexual problems. Most domains and symptoms returned to baseline levels by 12 months apart from body image, sexual enjoyment and male sexual problems. Future perspective was better than prior to treatment.
Conclusion: There is no overall difference in HRQOL between SC and LC neoadjuvant treatment strategies, in the first 12 months, after surgery. In the immediate postoperative period HRQOL was adversely affected in both groups but for the most part was temporary. Some residual sexual functioning concerns persisted at 12 months.
Keyword Health-related quality of life
Neoadjuvant chemoradiation
Rectal cancer
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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