Protective Effect of Regular Physical Activity on Depression After Myocardial Infarction: The HUNT Study

Ernstsen, Linda, Rangul, Vegar, Nauman, Javaid, Nes, Bjarne M., Dalen, Havard, Krokstad, Steinar, Lavie, Carl J., Blair, Steven N. and Wisloff, Ulrik (2016) Protective Effect of Regular Physical Activity on Depression After Myocardial Infarction: The HUNT Study. American Journal of Medicine, 129 1: 82-88.e1. doi:10.1016/j.amjmed.2015.08.012

Author Ernstsen, Linda
Rangul, Vegar
Nauman, Javaid
Nes, Bjarne M.
Dalen, Havard
Krokstad, Steinar
Lavie, Carl J.
Blair, Steven N.
Wisloff, Ulrik
Title Protective Effect of Regular Physical Activity on Depression After Myocardial Infarction: The HUNT Study
Journal name American Journal of Medicine   Check publisher's open access policy
ISSN 1555-7162
Publication date 2016-01
Year available 2015
Sub-type Article (original research)
DOI 10.1016/j.amjmed.2015.08.012
Open Access Status Not yet assessed
Volume 129
Issue 1
Start page 82
End page 88.e1
Total pages 8
Place of publication New York, United States
Publisher Elsevier
Collection year 2016
Language eng
Formatted abstract
Purpose: To study if physical activity within the recommended level over time was associated with risk of developing depression after the first myocardial infarction in older adults.

Methods: Men (n = 143) and women (n = 46) who had reached the age of 60 years in 2006-2008 who participated in the Nord-Trøndelag Health Study (HUNT1, 1984-1986; HUNT2, 1995-1997; HUNT3, 2006-2008) without any mental illness or cardiovascular disease at baseline in HUNT2 and who experienced their first myocardial infarction before HUNT3 were included. Based on the patterns of physical activity from HUNT1 to HUNT2, the sample was divided into 4 groups: persistently inactive, from active to inactive, from inactive to active, and persistently active. The primary outcome, post-myocardial infarction depression symptoms, was measured with the Hospital, Anxiety and Depression Scale in HUNT3.

Results: In HUNT3, 11% of participants had depression. After multivariable adjustment, those who were persistently active had significantly lower odds of being depressed (odds ratio 0.28; 95% confidence interval, 0.08-0.98) compared with those who were persistently inactive. Additionally, a significant test for trend (P = .033) of lowering odds of depression was observed across all 4 categories of physical activity patterns at baseline.

Conclusions: In this small sample of initially healthy adults, we observed a long-term protective effect of regular physical activity on the development of depression following myocardial infarction.
Keyword Depression
Myocardial infarction
Physical activity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
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