Interleukin-11 alters placentation and causes preeclampsia features in mice

Winship, Amy L., Koga, Kaori, Menkhorst, Ellen, Van Sinderen, Michelle, Rainczuk, Katarzyna, Nagai, Miwako, Cuman, Carly, Yap, Joanne, Zhang, Jian-Guo, Simmons, David, Young, Morag J. and Dimitriadis, Evdokia (2015) Interleukin-11 alters placentation and causes preeclampsia features in mice. Proceedings of the National Academy of Sciences of the United States of America, 112 52: 15928-15933. doi:10.1073/pnas.1515076112

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Author Winship, Amy L.
Koga, Kaori
Menkhorst, Ellen
Van Sinderen, Michelle
Rainczuk, Katarzyna
Nagai, Miwako
Cuman, Carly
Yap, Joanne
Zhang, Jian-Guo
Simmons, David
Young, Morag J.
Dimitriadis, Evdokia
Title Interleukin-11 alters placentation and causes preeclampsia features in mice
Journal name Proceedings of the National Academy of Sciences of the United States of America   Check publisher's open access policy
ISSN 1091-6490
0027-8424
Publication date 2015-12-29
Sub-type Article (original research)
DOI 10.1073/pnas.1515076112
Open Access Status File (Publisher version)
Volume 112
Issue 52
Start page 15928
End page 15933
Total pages 6
Place of publication Washington, DC, United States
Publisher National Academy of Sciences
Collection year 2016
Language eng
Abstract Preeclampsia is an insidious disease, unique to humans, affecting ∼8% of pregnancies. There are no early detection tests or pharmacological treatments. Impaired placentation is widely accepted to contribute to the pathogenesis. However, the mechanisms remain elusive, given the complications of studying first-trimester placental development in women. A major limitation for the study of new treatments is the lack of available animal models that recapitulate the full spectrum of preeclampsia features. We have developed a mouse model characterized by elevated levels of the cytokine Interleukin-11 (IL11). This study provides evidence of a novel pathway causative of preeclampsia features in vivo. It also provides a novel in vivo mouse model that is useful for preclinical studies to test potential therapeutics.
Keyword Cytokines
Placenta
Pregnancy
Trophoblast
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Biomedical Sciences Publications
 
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