Viridicatumtoxins: Expanding on a Rare Tetracycline Antibiotic Scaffold

Shang, Zhuo, Salim, Angela A., Khalil, Zeinab, Quezada, Michelle, Bernhardt, Paul V. and Capon, Robert J. (2015) Viridicatumtoxins: Expanding on a Rare Tetracycline Antibiotic Scaffold. Journal of Organic Chemistry, 80 24: 12501-12508. doi:10.1021/acs.joc.5b02367


Author Shang, Zhuo
Salim, Angela A.
Khalil, Zeinab
Quezada, Michelle
Bernhardt, Paul V.
Capon, Robert J.
Title Viridicatumtoxins: Expanding on a Rare Tetracycline Antibiotic Scaffold
Journal name Journal of Organic Chemistry   Check publisher's open access policy
ISSN 1520-6904
0022-3263
Publication date 2015-11-25
Year available 2015
Sub-type Article (original research)
DOI 10.1021/acs.joc.5b02367
Open Access Status Not yet assessed
Volume 80
Issue 24
Start page 12501
End page 12508
Total pages 8
Place of publication Washington, United States
Publisher American Chemical Society
Collection year 2016
Language eng
Formatted abstract
Viridicatumtoxins, which belong to a rare class of fungal tetracycline-like mycotoxins, were subjected to comprehensive spectroscopic and chemical analysis, leading to reassignment/assignment of absolute configurations and characterization of a remarkably acid-stable antibiotic scaffold. Structure activity relationship studies revealed exceptional growth inhibitory activity against vancomycin-resistant Enterococci (IC50 40 nM), >270-fold more potent than the commercial antibiotic oxytetracycline.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Chemistry and Molecular Biosciences
Institute for Molecular Bioscience - Publications
 
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