Organization of cholinergic, catecholaminergic, serotonergic and orexinergic nuclei in three strepsirrhine primates: Galago demidoff, Perodicticus potto and Lemur catta

Calvey, Tanya, Patzke, Nina, Kaswera-Kyamakya, Consolate, Gilissen, Emmanuel, Bertelsen, Mads F., Pettigrew, John D. and Manger, Paul R. (2015) Organization of cholinergic, catecholaminergic, serotonergic and orexinergic nuclei in three strepsirrhine primates: Galago demidoff, Perodicticus potto and Lemur catta. Journal of Chemical Neuroanatomy, 70 42-57. doi:10.1016/j.jchemneu.2015.10.002


Author Calvey, Tanya
Patzke, Nina
Kaswera-Kyamakya, Consolate
Gilissen, Emmanuel
Bertelsen, Mads F.
Pettigrew, John D.
Manger, Paul R.
Title Organization of cholinergic, catecholaminergic, serotonergic and orexinergic nuclei in three strepsirrhine primates: Galago demidoff, Perodicticus potto and Lemur catta
Journal name Journal of Chemical Neuroanatomy   Check publisher's open access policy
ISSN 0891-0618
1873-6300
Publication date 2015-12
Year available 2015
Sub-type Article (original research)
DOI 10.1016/j.jchemneu.2015.10.002
Volume 70
Start page 42
End page 57
Total pages 16
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2015
Language eng
Abstract The nuclear organization of the cholinergic, catecholaminergic, serotonergic and orexinergic systems in the brains of three species of strepsirrhine primates is presented. We aimed to investigate the nuclear complement of these neural systems in comparison to those of simian primates, megachiropterans and other mammalian species. The brains were coronally sectioned and immunohistochemically stained with antibodies against choline acetyltransferase, tyrosine hydroxylase, serotonin and orexin-A. The nuclei identified were identical among the strepsirrhine species investigated and identical to previous reports in simian primates. Moreover, a general similarity to other mammals was found, but specific differences in the nuclear complement highlighted potential phylogenetic interrelationships. The central feature of interest was the structure of the locus coeruleus complex in the primates, where a central compactly packed core (A6c) of tyrosine hydroxylase immunopositive neurons was surrounded by a shell of less densely packed (A6d) tyrosine hydroxylase immunopositive neurons. This combination of compact and diffuse divisions of the locus coeruleus complex is only found in primates and megachiropterans of all the mammalian species studied to date. This neural character, along with variances in a range of other neural characters, supports the phylogenetic grouping of primates with megachiropterans as a sister group.
Keyword Choline acetyltransferase
Tyrosine hydroxylase
Serotonin
Orexin
Mammalian evolution
Chiroptera
Neural systems
Base-Compositional Biases
Central-Nervous-System
Anthropoid Origins
Bat Problem
Rousettus-Aegyptiacus
Cladistic-Analysis
Terminal Networks
2 Megachiropteran
Enriched Tracers
Flying Primates
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2016 Collection
 
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