Chronic Leishmania donovani infection promotes bystander CD8 +-T-cell expansion and heterologous immunity

Polley, R, Sanos, SL, Prickett, S, Haque, A and Kaye, PM (2005) Chronic Leishmania donovani infection promotes bystander CD8 +-T-cell expansion and heterologous immunity. Infection and Immunity, 73 12: 7996-8001. doi:10.1128/IAI.73.12.7996-8001.2005

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Author Polley, R
Sanos, SL
Prickett, S
Haque, A
Kaye, PM
Title Chronic Leishmania donovani infection promotes bystander CD8 +-T-cell expansion and heterologous immunity
Journal name Infection and Immunity   Check publisher's open access policy
ISSN 0019-9567
Publication date 2005
Sub-type Article (original research)
DOI 10.1128/IAI.73.12.7996-8001.2005
Open Access Status File (Publisher version)
Volume 73
Issue 12
Start page 7996
End page 8001
Total pages 6
Language eng
Subject 2403 Immunology
Abstract It has been proposed that long-lived memory T cells generated by vaccination or infection reside within a memory compartment that has a finite size. Consequently, in a variety of acute infection models interclonal competition has been shown to lead to attrition of preexisting memory CD8 + T cells. Contrary to expectations, therefore, we found that chronic Leishmania donovani infection of Listeria-immune mice results in heightened protection against subsequent Listeria challenge. This protection was associated with bystander expansion of Listeria-specific CD8+ T cells and a bias in these cells toward a central memory T-cell phenotype with an enhanced capacity for gamma interferon production. We propose that splenomegaly, which is characteristic of visceral leishmaniasis and other tropical infections, may help promote heterologous immunity by resetting the size of the memory compartment during chronic infection. Copyright
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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Citation counts: TR Web of Science Citation Count  Cited 13 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 14 times in Scopus Article | Citations
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