Lymphotoxin alpha and tumour necrosis factor are not required for control of parasite growth, but differentially regulate cytokine production during Plasmodium chabaudi chabaudi AS infection

Clark, K., Kulk, N., Amante, F., Haque, A. and Engwerda, C. (2007) Lymphotoxin alpha and tumour necrosis factor are not required for control of parasite growth, but differentially regulate cytokine production during Plasmodium chabaudi chabaudi AS infection. Parasite Immunology, 29 3: 153-158. doi:10.1111/j.1365-3024.2006.00930.x


Author Clark, K.
Kulk, N.
Amante, F.
Haque, A.
Engwerda, C.
Title Lymphotoxin alpha and tumour necrosis factor are not required for control of parasite growth, but differentially regulate cytokine production during Plasmodium chabaudi chabaudi AS infection
Formatted title
Lymphotoxin alpha and tumour necrosis factor are not required for control of parasite growth, but differentially regulate cytokine production during Plasmodium chabaudi chabaudi AS infection
Journal name Parasite Immunology   Check publisher's open access policy
ISSN 0141-9838
1365-3024
Publication date 2007-03
Sub-type Article (original research)
DOI 10.1111/j.1365-3024.2006.00930.x
Open Access Status Not yet assessed
Volume 29
Issue 3
Start page 153
End page 158
Total pages 6
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Formatted abstract
Tumour necrosis factor (TNF) plays important roles in the pathogenesis of severe malaria, as well as in the generation of immune responses against malaria parasites. However, far less is known about the role of the closely related TNF family member lymphotoxin alpha (LTα) during malaria. We have used mice deficient in either TNF or LTα, as well as chimeric mice generated using donor bone marrow from these animals, to study the roles of these cytokines following Plasmodium chabaudi chabaudi AS infection. TNF and LTα were not required for the resolution of P. chabaudi chabaudi AS blood-stage infection. However, LTα, but not TNF, was necessary for early IFNγ production and the regulation of IFNγ production later in infection. A similar delay to that found for IFNγ production was also observed for TNF production in LTα-deficient mice, compared with control mice. These results identify divergent roles for TNF and LTα in the regulation of host immune responses during P. chabaudi chabaudi AS infection.
Keyword Lymphotoxin alpha
Malaria
Plasmodium chabaudi chabaudi AS
Tumour necrosis factor
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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