Age-dependent and -independent changes in attention-deficit/hyperactivity disorder (ADHD) during spatial working memory performance

Bollmann, Steffen, Ghisleni, Carmen, Poil, Simon-Shlomo, Martin, Ernst, Ball, Juliane, Eich-Höchli, Dominique, Klaver, Peter, O’Gorman, Ruth L., Michels, Lars and Brandeis, Daniel (2015) Age-dependent and -independent changes in attention-deficit/hyperactivity disorder (ADHD) during spatial working memory performance. The World Journal of Biological Psychiatry, . doi:10.3109/15622975.2015.1112034


Author Bollmann, Steffen
Ghisleni, Carmen
Poil, Simon-Shlomo
Martin, Ernst
Ball, Juliane
Eich-Höchli, Dominique
Klaver, Peter
O’Gorman, Ruth L.
Michels, Lars
Brandeis, Daniel
Title Age-dependent and -independent changes in attention-deficit/hyperactivity disorder (ADHD) during spatial working memory performance
Journal name The World Journal of Biological Psychiatry   Check publisher's open access policy
ISSN 1562-2975
1814-1412
Publication date 2015
Year available 2015
Sub-type Article (original research)
DOI 10.3109/15622975.2015.1112034
Open Access Status Not Open Access
Total pages 12
Place of publication Abingdon, Oxfordshire, United Kingdom
Publisher Taylor & Francis
Collection year 2016
Language eng
Formatted abstract
Objectives: Attention-deficit/hyperactivity disorder (ADHD) has been associated with spatial working memory as well as frontostriatal core deficits. However, it is still unclear how the link between these frontostriatal deficits and working memory function in ADHD differs in children and adults. This study examined spatial working memory in adults and children with ADHD, focussing on identifying regions demonstrating age-invariant or age-dependent abnormalities.

Methods: We used functional magnetic resonance imaging to examine a group of 26 children and 35 adults to study load manipulated spatial working memory in patients and controls.

Results: In comparison to healthy controls, patients demonstrated reduced positive parietal and frontostriatal load effects, i.e., less increase in brain activity from low to high load, despite similar task performance. In addition, younger patients showed negative load effects, i.e., a decrease in brain activity from low to high load, in medial prefrontal regions. Load effect differences between ADHD and controls that differed between age groups were found predominantly in prefrontal regions. Age-invariant load effect differences occurred predominantly in frontostriatal regions.

Conclusions: The age-dependent deviations support the role of prefrontal maturation and compensation in ADHD, while the age-invariant alterations observed in frontostriatal regions provide further evidence that these regions reflect a core pathophysiology in ADHD.
Keyword ADHD
Basal ganglia
Functional magnetic resonance imaging
Prefrontal cortex
Spatial working memory
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
Centre for Advanced Imaging Publications
 
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Created: Tue, 12 Jan 2016, 11:44:40 EST by Steffen Bollmann on behalf of Centre for Advanced Imaging