Bench to bedside: NK cells and control of metastasis

Krasnova, Yelena, Putz, Eva Maria, Smyth, Mark J. and Souza-Fonseca-Guimaraes, Fernando (2015) Bench to bedside: NK cells and control of metastasis. Clinical Immunology, . doi:10.1016/j.clim.2015.10.001


Author Krasnova, Yelena
Putz, Eva Maria
Smyth, Mark J.
Souza-Fonseca-Guimaraes, Fernando
Title Bench to bedside: NK cells and control of metastasis
Journal name Clinical Immunology   Check publisher's open access policy
ISSN 1521-7035
1521-6616
Publication date 2015-10-23
Sub-type Article (original research)
DOI 10.1016/j.clim.2015.10.001
Open Access Status Not Open Access
Total pages 10
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Collection year 2016
Language eng
Abstract Natural killer (NK) cells play a critical role in host immune responses against tumor growth and metastasis. The numerous mechanisms used by NK cells to regulate and control cancer metastasis include interactions with tumor cells via specific receptors and ligands as well as direct cytotoxicity and cytokine-induced effector mechanisms. NK cells also play a role in tumor immunosurveillance and inhibition of metastases formation by recognition and killing of tumor cells. In this review, we provide an overview of the molecular mechanisms of NK cell responses against tumor metastases and discuss multiple strategies by which tumors evade NK cell-mediated surveillance. With an increasing understanding of the molecular mechanisms driving NK cell activity, there is a growing potential for the development of new cancer immunotherapies. Here we provide a historical background on NK cell-based therapies and discuss the implications of recent and ongoing clinical trials using novel NK cell-based immunotherapy.
Keyword Antitumor control
Clinical trials and emerging therapies
Immunosurveillance
Integration of cellular signaling pathways
Metastasis
NK cells
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
 
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