Sharing a placenta is associated with a greater similarity in DNA methylation in monochorionic versus dichorionic twin pars in blood at age 14

Bui, Masato, Benyamin, Beben, Shah, Sonia, Henders, Anjali K., Martin, Nicholas G., Montgomery, Grant W. and McRae, Allan F. (2015) Sharing a placenta is associated with a greater similarity in DNA methylation in monochorionic versus dichorionic twin pars in blood at age 14. Twin Research and Human Genetics, 18 6: 680-685. doi:10.1017/thg.2015.87


Author Bui, Masato
Benyamin, Beben
Shah, Sonia
Henders, Anjali K.
Martin, Nicholas G.
Montgomery, Grant W.
McRae, Allan F.
Title Sharing a placenta is associated with a greater similarity in DNA methylation in monochorionic versus dichorionic twin pars in blood at age 14
Journal name Twin Research and Human Genetics   Check publisher's open access policy
ISSN 1839-2628
1832-4274
Publication date 2015-12-01
Sub-type Article (original research)
DOI 10.1017/thg.2015.87
Open Access Status Not Open Access
Volume 18
Issue 6
Start page 680
End page 685
Total pages 6
Place of publication Cambridge, United Kingdom
Publisher Cambridge University Press
Collection year 2016
Language eng
Subject 2716 Genetics (clinical)
2729 Obstetrics and Gynaecology
2735 Pediatrics, Perinatology, and Child Health
Formatted abstract
Monozygotic (MZ) twins provide a natural system for investigating developmental plasticity and the potential epigenetic origins of disease. A major difference in the intrauterine environment between MZ pairs is whether they share a common placenta or have separate placentas. Using DNA methylation measured at >400,000 points in the genome on the Illumina HumanMethylation450 array, we demonstrate that the co-twins of MZ pairs (average age of 14) that shared a common placenta (n = 18 pairs) have more similar DNA methylation levels in blood throughout the genome relative to those with separate placentas (n = 16 pairs). Functional annotation of the genomic regions that show significantly different correlation between monochorionic (MC) and dichorionic (DC) MZ pairs found an over-representation of genes involved in the regulation of transcription, neuronal development, and cellular differentiation. These results support the idea that prenatal environmental exposures may have a lasting effect on an individual's epigenetic landscape, and the potential for these changes to have functional consequences.
Keyword Chorionicity
DNA methylation
Monozygotic twins
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2016 Collection
 
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