Systematic evaluation of self-adjuvanting lipopeptide nano-vaccine platforms for the induction of potent CD8+ T-cell responses

Apte, Simon H., Stephenson, Rachel J., Simerska, Pavla, Groves, Penny L., Aljohani, Salwa, Eskandari, Sharareh, Toth, Istvan and Doolan, Denise L. (2016) Systematic evaluation of self-adjuvanting lipopeptide nano-vaccine platforms for the induction of potent CD8+ T-cell responses. Nanomedicine, 11 2: 137-152. doi:10.2217/nnm.15.184


Author Apte, Simon H.
Stephenson, Rachel J.
Simerska, Pavla
Groves, Penny L.
Aljohani, Salwa
Eskandari, Sharareh
Toth, Istvan
Doolan, Denise L.
Title Systematic evaluation of self-adjuvanting lipopeptide nano-vaccine platforms for the induction of potent CD8+ T-cell responses
Formatted title
Systematic evaluation of self-adjuvanting lipopeptide nano-vaccine platforms for the induction of potent CD8+ T-cell responses
Journal name Nanomedicine   Check publisher's open access policy
ISSN 1748-6963
1743-5889
Publication date 2016-01
Sub-type Article (original research)
DOI 10.2217/nnm.15.184
Open Access Status Not Open Access
Volume 11
Issue 2
Start page 137
End page 152
Total pages 16
Place of publication London, United Kingdom
Publisher Future Medicine
Collection year 2017
Language eng
Formatted abstract
Aim: Systematically evaluate lipid core peptide vaccine delivery platforms to identify core features promoting strong CD8+ T-cell responses. Materials & methods: Three different self-adjuvanting lipid core peptide nanovaccines each comprising four copies of the dominant ovalbumin CD8+ T-cell epitope and varying in the utilization of a polylysine or glucose core with 2-amino-hexadecanoic acid (C16) or 2-amino-dodecanoic acid (C12) lipids were synthesized. Vaccines were tested for ability to induce CD8+ T-cell responses and inhibit tumor growth in vivo. Results: The construct utilizing C12 lipids and polylysine core induced very robust effector T cells shown to have in vivo effector capability as demonstrated by in vivo cytotoxicity and ability to inhibit tumor growth as well as modulation of dendritic cell activation. Conclusion: The C12 polylysine platform was an effective configuration for induction of potent CD8+ T-cell responses.
Keyword CD8+ T cells
Dendritic cells
Lipid core peptide
Nanovaccine
Self-adjuvant
Vaccine
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
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