Can paracetamol (acetaminophen) be administered to patients with liver impairment?

Hayward, Kelly L., Powell, Elizabeth E., Irvine, Katharine M. and Martin, Jennifer H. (2015) Can paracetamol (acetaminophen) be administered to patients with liver impairment?. British Journal of Clinical Pharmacology, 81 2: 210-222. doi:10.1111/bcp.12802

Author Hayward, Kelly L.
Powell, Elizabeth E.
Irvine, Katharine M.
Martin, Jennifer H.
Title Can paracetamol (acetaminophen) be administered to patients with liver impairment?
Journal name British Journal of Clinical Pharmacology   Check publisher's open access policy
ISSN 1365-2125
Publication date 2015-12-25
Year available 2015
Sub-type Article (original research)
DOI 10.1111/bcp.12802
Open Access Status Not yet assessed
Volume 81
Issue 2
Start page 210
End page 222
Total pages 13
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell Publishing
Collection year 2016
Language eng
Abstract Although 60 years have passed since it became widely available on the therapeutic market, paracetamol dosage in patients with liver disease remains a controversial subject. Fulminant hepatic failure has been a well documented consequence of paracetamol overdose since its introduction, while short and long term use have both been associated with elevation of liver transaminases, a surrogate marker for acute liver injury. From these reports it has been assumed that paracetamol use should be restricted or the dosage reduced in patients with chronic liver disease. We review the factors that have been purported to increase risk of hepatocellular injury from paracetamol and the pharmacokinetic alterations in different pathologies of chronic liver disease which may affect this risk. We postulate that inadvertent under-dosing may result in concentrations too low to enable efficacy. Specific research to improve the evidence base for prescribing paracetamol in patients with different aetiologies of chronic liver disease is needed.
Keyword Analgesia
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
UQ Diamantina Institute Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in Thomson Reuters Web of Science Article
Scopus Citation Count Cited 1 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 12 Jan 2016, 00:29:19 EST by System User on behalf of Scholarly Communication and Digitisation Service