Spleen volume variation in patients with locally advanced non-small cell lung cancer receiving platinum-based chemo-radiotherapy

Wen, Shu Wen, Everitt, Sarah J., Bedo, Justin, Chabrot, Marine, Ball, David L., Solomon, Benjamin, MacManus, Michael, Hicks, Rodney J., Möller, Andreas and Leimgruber, Antoine (2015) Spleen volume variation in patients with locally advanced non-small cell lung cancer receiving platinum-based chemo-radiotherapy. PloS One, 10 11: . doi:10.1371/journal.pone.0142608


Author Wen, Shu Wen
Everitt, Sarah J.
Bedo, Justin
Chabrot, Marine
Ball, David L.
Solomon, Benjamin
MacManus, Michael
Hicks, Rodney J.
Möller, Andreas
Leimgruber, Antoine
Title Spleen volume variation in patients with locally advanced non-small cell lung cancer receiving platinum-based chemo-radiotherapy
Journal name PloS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2015-11-24
Sub-type Article (original research)
DOI 10.1371/journal.pone.0142608
Open Access Status DOI
Volume 10
Issue 11
Total pages 8
Place of publication San Francisco, United States
Publisher Public Library of Science
Collection year 2016
Language eng
Abstract There is renewed interest in the immune regulatory role of the spleen in oncology. To date, very few studies have examined macroscopic variations of splenic volume in the setting of cancer, prior to or during therapy, especially in humans. Changes in splenic volume may be associated with changes in splenic function. The purpose of this study was to investigate variations in spleen volume in NSCLC patients during chemo-radiotherapy. Sixty patients with stage I-IIIB NSCLC underwent radiotherapy (60Gy/30 fractions) for six weeks with concomitant carboplatin/paclitaxel (Ca/P; n = 32) or cisplatin/etoposide (Ci/E; n = 28). A baseline PET/CT scan was performed within 2 weeks prior to treatment and during Weeks 2 and 4 of chemo-radiotherapy. Spleen volume was measured by contouring all CT slices. Significant macroscopic changes in splenic volume occurred early after the commencement of treatment. A significant decrease in spleen volume was observed for 66% of Ca/P and 79% of Ci/E patients between baseline and Week 2. Spleen volume was decreased by 14.2% for Ca/P (p<0.001) and 19.3% for Ci/E (p<0.001) patients. By Week 4, spleen volume was still significantly decreased for Ca/P patients compared to baseline, while for Ci/E patients, spleen volume returned to above baseline levels. This is the first report demonstrating macroscopic changes in the spleen in NSCLC patients undergoing radical chemo-radiotherapy that can be visualized by non-invasive imaging.
Keyword Splenic volume
Concurrent chemotherapy
CT
Trial
Induction
Radiation
Size
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
 
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