Multiple neural circuits mediating airway sensations: recent advances in the neurobiology of the urge-to-cough

Driessen, Alexandria K., Farrell, Michael J., Mazzone, Stuart B. and McGovern, Alice E. (2015) Multiple neural circuits mediating airway sensations: recent advances in the neurobiology of the urge-to-cough. Respiratory Physiology and Neurobiology, 226 115-120. doi:10.1016/j.resp.2015.09.017


Author Driessen, Alexandria K.
Farrell, Michael J.
Mazzone, Stuart B.
McGovern, Alice E.
Title Multiple neural circuits mediating airway sensations: recent advances in the neurobiology of the urge-to-cough
Journal name Respiratory Physiology and Neurobiology   Check publisher's open access policy
ISSN 1878-1519
1569-9048
Publication date 2015-10-09
Year available 2015
Sub-type Article (original research)
DOI 10.1016/j.resp.2015.09.017
Open Access Status Not Open Access
Volume 226
Start page 115
End page 120
Total pages 6
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2016
Language eng
Abstract The respiratory system is densely innervated by sensory neurons arising from the jugular (superior) and nodose (inferior) vagal ganglia. However, a distinction exists between jugular and nodose neurons as these ganglia developmentally originate from the neural crest and the epibranchial placodes, respectively. This different embryological origin underpins an important source of heterogeneity in vagal afferent biology, and may extend to include fundamentally different central neural circuits that are in receipt of jugular versus nodose afferent inputs. Indeed, recent studies using viral tract tracing and human brain imaging support the notion that airway sensors contribute inputs to multiple central circuits. Understanding the neural pathways arising from the airways and lungs may provide novel insights into aberrant sensations, such as the urge-to-cough, characteristic of respiratory disease.
Keyword Somatosensory
Viscerosensory
Anterograde
Herpes virus
fMRI
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Biomedical Sciences Publications
 
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