Functional connectivity hubs could serve as a potential biomarker in alzheimer's disease: a reproducible study

Sui, Xiuchao, Zhu, Maohu, Cui, Yue, Yu, Chunshui, Sui, Jing, Zhang, Xinqing, Liu, Jieqiong, Duan, Yunyun, Zhang, Zengqiang, Wang, Luning, Zhang, Xi and Jiang, Tianzi (2015) Functional connectivity hubs could serve as a potential biomarker in alzheimer's disease: a reproducible study. Current Alzheimer Research, 12 10: 974-983. doi:10.2174/1567205012666150710111615


Author Sui, Xiuchao
Zhu, Maohu
Cui, Yue
Yu, Chunshui
Sui, Jing
Zhang, Xinqing
Liu, Jieqiong
Duan, Yunyun
Zhang, Zengqiang
Wang, Luning
Zhang, Xi
Jiang, Tianzi
Title Functional connectivity hubs could serve as a potential biomarker in alzheimer's disease: a reproducible study
Journal name Current Alzheimer Research   Check publisher's open access policy
ISSN 1567-2050
1875-5828
Publication date 2015-12-01
Sub-type Article (original research)
DOI 10.2174/1567205012666150710111615
Open Access Status Not Open Access
Volume 12
Issue 10
Start page 974
End page 983
Total pages 10
Place of publication Bussum, Netherlands
Publisher Bentham Science Publishers
Collection year 2016
Language eng
Abstract Cortical hubs that link functionally specialized neural systems are crucial for cognition. Evidence suggests that the location and organization of hubs are related to Alzheimer’s disease (AD). However, two issues remain unclear: (i) where and how hubs change in AD, and (ii) whether hubs could be a potential pre-diagnosis biomarker for mild cognitive impairment (MCI) - a prodromal phase of AD. Accordingly, we examined the functional connectivity density (FCD) in two cohorts of resting-state functional magnetic resonance imaging (fMRI) scans (26 AD, 27 controls; 33 AD, 21 controls) and revealed consistently vulnerable FCD hub regions in AD compared with controls: within the default mode network, short-range FCD decreases in the posterior cingulate cortex and increases in the medial prefrontal cortex; within the frontal lobe, long-range FCD increases in the medial prefrontal cortex, superior frontal gyrus and middle frontal gyrus. Furthermore, FCD correlates with cognitive score and could distinguish MCI from controls with high accuracy (71.08% in dataset 1, 81% in dataset 2). By reflecting a robust and reproducible global shift in brain functions, FCD provides an fMRI biomarker for the underlying mechanism in AD.
Keyword Alzheimer's disease
Biomarker
Classification
Functional connectivity density
Mild cognitive impairment
Resting state functional MRI
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2016 Collection
 
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