Restricted versus continued standard caloric intake during the management of refeeding syndrome in critically ill adults: A randomised, parallel-group, multicentre, single-blind controlled trial

Doig, Gordon S., Simpson, Fiona, Heighes, Philippa T., Bellomo, Rinaldo, Chesher, Douglas, Caterson, Ian D., Reade, Michael C. and Harrigan, Peter W. J. (2015) Restricted versus continued standard caloric intake during the management of refeeding syndrome in critically ill adults: A randomised, parallel-group, multicentre, single-blind controlled trial. The Lancet Respiratory Medicine, 3 12: 943-952. doi:10.1016/S2213-2600(15)00418-X


Author Doig, Gordon S.
Simpson, Fiona
Heighes, Philippa T.
Bellomo, Rinaldo
Chesher, Douglas
Caterson, Ian D.
Reade, Michael C.
Harrigan, Peter W. J.
Title Restricted versus continued standard caloric intake during the management of refeeding syndrome in critically ill adults: A randomised, parallel-group, multicentre, single-blind controlled trial
Journal name The Lancet Respiratory Medicine   Check publisher's open access policy
ISSN 2213-2619
2213-2600
Publication date 2015-12-01
Year available 2015
Sub-type Article (original research)
DOI 10.1016/S2213-2600(15)00418-X
Open Access Status Not yet assessed
Volume 3
Issue 12
Start page 943
End page 952
Total pages 10
Place of publication London, United Kingdom
Publisher Lancet Publishing Group
Collection year 2016
Language eng
Formatted abstract
Background Equipoise exists regarding the benefits of restricting caloric intake during electrolyte replacement for refeeding syndrome, with half of intensive care specialists choosing to continue normal caloric intake. We aimed to assess whether energy restriction affects the duration of critical illness, and other measures of morbidity, compared with standard care.

Methods We did a randomised, multicentre, single-blind clinical trial in 13 hospital intensive care units (ICUs) in Australia (11 sites) and New Zealand (two sites). Adult critically ill patients who developed refeeding syndrome within 72 h of commencing nutritional support in the ICU were enrolled and allocated to receive continued standard nutritional support or protocolised caloric restriction. 1:1 computer-based randomisation was done in blocks of variable size, stratified by enrolment serum phosphate concentration (>0·32 mmol/L vs ≤0·32 mmol/L) and body-mass index (BMI; >18 kg/m 2 vs ≤18 kg/m 2 ). The primary outcome was the number of days alive after ICU discharge, with 60 day follow-up, in a modified intention-to-treat population of all randomly allocated patients except those mistakenly enrolled. Days alive after ICU discharge was a composite outcome based on ICU length of stay, overall survival time, and mortality. The Refeeding Syndrome Trial was registered with the Australian and New Zealand Clinical Trials Registry (ANZCTR number 12609001043224).

Findings Between Dec 3, 2010, and Aug 13, 2014, we enrolled 339 adult critically ill patients: 170 were randomly allocated to continued standard nutritional support and 169 to protocolised caloric restriction. During the 60 day follow-up, the mean number of days alive after ICU discharge in 165 assessable patients in the standard care group was 39·9 (95% CI 36·4–43·7) compared with 44·8 (95% CI 40·9–49·1) in 166 assessable patients in the caloric restriction group (difference 4·9 days, 95% CI −2·3 to 13·6, p=0·19). Nevertheless, protocolised caloric restriction improved key individual components of the primary outcome: more patients were alive at day 60 (128 [78%] of 163 vs 149 [91%] of 164, p=0·002) and overall survival time was increased (48·9 [SD 1·46] days vs 53·65 [0·97] days, log-rank p=0·002).

Interpretation Protocolised caloric restriction is a suitable therapeutic option for critically ill adults who develop refeeding syndrome. We did not identify any safety concerns associated with the use of protocolised caloric restriction.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 2 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 4 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 03 Jan 2016, 00:22:20 EST by System User on behalf of Scholarly Communication and Digitisation Service