Insulin receptor isoforms: An integrated view focused on gestational diabetes mellitus

Westermeier, F., Saez, T., Arroyo, P., Toledo, F., Gutierrez, J., Sanhueza, C., Pardo, F., Leiva, A. and Sobrevia, L. (2015) Insulin receptor isoforms: An integrated view focused on gestational diabetes mellitus. Diabetes/Metabolism Research and Reviews, 32 4: 350-365. doi:10.1002/dmrr.2729


Author Westermeier, F.
Saez, T.
Arroyo, P.
Toledo, F.
Gutierrez, J.
Sanhueza, C.
Pardo, F.
Leiva, A.
Sobrevia, L.
Title Insulin receptor isoforms: An integrated view focused on gestational diabetes mellitus
Journal name Diabetes/Metabolism Research and Reviews   Check publisher's open access policy
ISSN 1520-7560
Publication date 2015-11-25
Year available 2015
Sub-type Article (original research)
DOI 10.1002/dmrr.2729
Open Access Status Not yet assessed
Volume 32
Issue 4
Start page 350
End page 365
Total pages 16
Place of publication Chichester, West Sussex, United Kingdom
Publisher John Wiley & Sons
Collection year 2016
Language eng
Abstract The human insulin receptor (IR) exists in two isoforms that differ by the absence (IR-A) or the presence (IR-B) of a 12-amino acid segment encoded by exon 11. Both isoforms are functionally distinct regarding their binding affinities and intracellular signalling. However, the underlying mechanisms related to their cellular functions in several tissues are only partially understood. In this review, we summarize the current knowledge in this field regarding the alternative splicing of IR isoform, tissue-specific distribution and signalling both in physiology and disease, with an emphasis on the human placenta in gestational diabetes mellitus (GDM). Furthermore, we discuss the clinical relevance of IR isoforms highlighted by findings that show altered insulin signalling due to differential IR-A and IR-B expression in human placental endothelium in GDM pregnancies. Future research and clinical studies focused on the role of IR isoform signalling might provide novel therapeutic targets for treating GDM to improve the adverse maternal and neonatal outcomes.
Keyword Insulin receptor
Gestational diabetes
Placenta
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2016 Collection
 
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