Quantum metrology and its application in biology

Taylor, Michael A. and Bowen, Warwick P. (2016) Quantum metrology and its application in biology. Physics Reports, 615 1-59. doi:10.1016/j.physrep.2015.12.002

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Author Taylor, Michael A.
Bowen, Warwick P.
Title Quantum metrology and its application in biology
Journal name Physics Reports   Check publisher's open access policy
ISSN 0370-1573
1873-6270
Publication date 2016-02-23
Year available 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.physrep.2015.12.002
Open Access Status File (Author Post-print)
Volume 615
Start page 1
End page 59
Total pages 59
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2016
Language eng
Formatted abstract
Quantum metrology provides a route to overcome practical limits in sensing devices. It holds particular relevance to biology, where sensitivity and resolution constraints restrict applications both in fundamental biophysics and in medicine. Here, we review quantum metrology from this biological context, focusing on optical techniques due to their particular relevance for biological imaging, sensing, and stimulation. Our understanding of quantum mechanics has already enabled important applications in biology, including positron emission tomography (PET) with entangled photons, magnetic resonance imaging (MRI) using nuclear magnetic resonance, and bio-magnetic imaging with superconducting quantum interference devices (SQUIDs). In quantum metrology an even greater range of applications arise from the ability to not just understand, but to engineer, coherence and correlations at the quantum level. In the past few years, quite dramatic progress has been seen in applying these ideas into biological systems. Capabilities that have been demonstrated include enhanced sensitivity and resolution, immunity to imaging artefacts and technical noise, and characterization of the biological response to light at the single-photon level. New quantum measurement techniques offer even greater promise, raising the prospect for improved multi-photon microscopy and magnetic imaging, among many other possible applications. Realization of this potential will require cross-disciplinary input from researchers in both biology and quantum physics. In this review we seek to communicate the developments of quantum metrology in a way that is accessible to biologists and biophysicists, while providing sufficient details to allow the interested reader to obtain a solid understanding of the field. We further seek to introduce quantum physicists to some of the central challenges of optical measurements in biological science. We hope that this will aid in bridging the communication gap that exists between the fields, and thereby guide the future development of this multidisciplinary research area.
Keyword Quantum metrology
Biology
Cell
Coherence
Quantum correlations
Squeezed state
NOON state
Shot noise
Quantum Fisher information
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: School of Mathematics and Physics
Official 2016 Collection
 
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Citation counts: TR Web of Science Citation Count  Cited 5 times in Thomson Reuters Web of Science Article | Citations
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