A network of autism linked genes stabilizes two pools of synaptic GABAA receptors

Tong, Xia-Jing, Hu, Zhitao, Liu, Yu, Anderson, Dorian and Kaplan, Joshua M. (2015) A network of autism linked genes stabilizes two pools of synaptic GABAA receptors. eLife, 4 e09648: . doi:10.7554/eLife.09648


Author Tong, Xia-Jing
Hu, Zhitao
Liu, Yu
Anderson, Dorian
Kaplan, Joshua M.
Title A network of autism linked genes stabilizes two pools of synaptic GABAA receptors
Journal name eLife   Check publisher's open access policy
ISSN 2050-084X
Publication date 2015-11-17
Year available 2015
Sub-type Article (original research)
DOI 10.7554/eLife.09648
Open Access Status DOI
Volume 4
Issue e09648
Total pages 19
Place of publication Cambridge, United Kingdom
Publisher eLife Sciences Publications
Collection year 2016
Language eng
Formatted abstract
Changing receptor abundance at synapses is an important mechanism for regulating synaptic strength. Synapses contain two pools of receptors, immobilized and diffusing receptors, both of which are confined to post-synaptic elements. Here we show that immobile and diffusing GABAA receptors are stabilized by distinct synaptic scaffolds at C. elegans neuromuscular junctions. Immobilized GABAA receptors are stabilized by binding to FRM-3/EPB4.1 and LIN-2A/CASK. Diffusing GABAA receptors are stabilized by the synaptic adhesion molecules Neurexin and Neuroligin. Inhibitory post-synaptic currents are eliminated in double mutants lacking both scaffolds. Neurexin, Neuroligin, and CASK mutations are all linked to Autism Spectrum Disorders (ASD). Our results suggest that these mutations may directly alter inhibitory transmission, which could contribute to the developmental and cognitive deficits observed in ASD. 
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
Queensland Brain Institute Publications
 
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