Targeted Therapies for Triple-Negative Breast Cancer: Combating a Stubborn Disease

Kalimutho, Murugan, Parsons, Kate, Mittal, Deepak, Lopez, J.Alejandro, Srihari, Sriganesh and Khanna, Kum Kum (2015) Targeted Therapies for Triple-Negative Breast Cancer: Combating a Stubborn Disease. Trends in Pharmacological Sciences, 36 12: 822-846. doi:10.1016/j.tips.2015.08.009


Author Kalimutho, Murugan
Parsons, Kate
Mittal, Deepak
Lopez, J.Alejandro
Srihari, Sriganesh
Khanna, Kum Kum
Title Targeted Therapies for Triple-Negative Breast Cancer: Combating a Stubborn Disease
Journal name Trends in Pharmacological Sciences   Check publisher's open access policy
ISSN 1873-3735
0165-6147
Publication date 2015-12-01
Year available 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.tips.2015.08.009
Open Access Status Not yet assessed
Volume 36
Issue 12
Start page 822
End page 846
Total pages 25
Place of publication Oxford, United Kingdom
Publisher Elsevier
Collection year 2016
Language eng
Abstract Triple-negative breast cancers (TNBCs) constitute a heterogeneous subtype of breast cancers that have a poor clinical outcome. Although no approved targeted therapy is available for TNBCs, molecular-profiling efforts have revealed promising molecular targets, with several candidate compounds having now entered clinical trials for TNBC patients. However, initial results remain modest, thereby highlighting challenges potentially involving intra- and intertumoral heterogeneity and acquisition of therapy resistance. We present a comprehensive review on emerging targeted therapies for treating TNBCs, including the promising approach of immunotherapy and the prognostic value of tumor-infiltrating lymphocytes. We discuss the impact of pathway rewiring in the acquisition of drug resistance, and the prospect of employing combination therapy strategies to overcome challenges towards identifying clinically-viable targeted treatment options for TNBC.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2016 Collection
Institute for Molecular Bioscience - Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 7 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 11 times in Scopus Article | Citations
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