Functional localization of the human color center by decreased water displacement using diffusion-weighted fMRI

Williams, Rebecca J., Reutens, David C. and Hocking, Julia (2015) Functional localization of the human color center by decreased water displacement using diffusion-weighted fMRI. Brain and Behavior, 5 11: . doi:10.1002/brb3.408


Author Williams, Rebecca J.
Reutens, David C.
Hocking, Julia
Title Functional localization of the human color center by decreased water displacement using diffusion-weighted fMRI
Journal name Brain and Behavior   Check publisher's open access policy
ISSN 2162-3279
Publication date 2015
Sub-type Article (original research)
DOI 10.1002/brb3.408
Open Access Status DOI
Volume 5
Issue 11
Total pages 12
Place of publication Chichester, West Sussex, United Kingdom
Publisher John Wiley and Sons
Collection year 2016
Language eng
Subject 2802 Behavioral Neuroscience
Formatted abstract
Introduction: Decreased water displacement following increased neural activity has been observed using diffusion-weighted functional MRI (DfMRI) at high b-values. The physiological mechanisms underlying the diffusion signal change may be unique from the standard blood oxygenation level-dependent (BOLD) contrast and closer to the source of neural activity. Whether DfMRI reflects neural activity more directly than BOLD outside the primary cerebral regions remains unclear.

Methods: Colored and achromatic Mondrian visual stimuli were statistically contrasted to functionally localize the human color center Area V4 in neurologically intact adults. Spatial and temporal properties of DfMRI and BOLD activation were examined across regions of the visual cortex.

Results: At the individual level, DfMRI activation patterns showed greater spatial specificity to V4 than BOLD. The BOLD activation patterns were more prominent in the primary visual cortex than DfMRI, where activation was localized to the ventral temporal lobe. Temporally, the diffusion signal change in V4 and V1 both preceded the corresponding hemodynamic response, however the early diffusion signal change was more evident in V1.

Conclusions: DfMRI may be of use in imaging applications implementing cognitive subtraction paradigms, and where highly precise individual functional localization is required.
Keyword Area V4
BOLD
DfMRI
Diffusion MRI
fMRI
Magnetic resonance imaging
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
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Created: Tue, 22 Dec 2015, 09:04:55 EST by Susan Day on behalf of Scholarly Communication and Digitisation Service