Increased risk of melanoma in patients with chronic lymphocytic leukaemia: systematic review and meta-analysis of cohort studies

Olsen, Catherine M., Lane, Steven W. and Green, Adèle C. (2015) Increased risk of melanoma in patients with chronic lymphocytic leukaemia: systematic review and meta-analysis of cohort studies. Melanoma Research, 26 2: 188-194. doi:10.1097/CMR.0000000000000219


Author Olsen, Catherine M.
Lane, Steven W.
Green, Adèle C.
Title Increased risk of melanoma in patients with chronic lymphocytic leukaemia: systematic review and meta-analysis of cohort studies
Journal name Melanoma Research   Check publisher's open access policy
ISSN 1473-5636
0960-8931
Publication date 2015-12-01
Sub-type Article (original research)
DOI 10.1097/CMR.0000000000000219
Open Access Status Not Open Access
Volume 26
Issue 2
Start page 188
End page 194
Total pages 7
Place of publication London, United Kingdom
Publisher Lippincott Williams and Wilkins
Collection year 2016
Language eng
Formatted abstract
An increased risk of melanoma has been variously reported in patients with chronic lymphocytic leukaemia (CLL), analogous with other immunosuppressed populations. To fully assess this association, we performed a systematic review and meta-analysis of available evidence from observational cohort studies. All such longitudinal studies of patients diagnosed with CLL that enabled quantitative assessment of the risk of melanoma compared with the general population were eligible. We identified seven studies from a search of all published literature to July 2014 in Medline, Embase and ISI science citation index databases. Data were pooled using a random-effects model. There was an almost four-fold increase in the risk of melanoma in patients with CLL compared with the general population (pooled standardized incidence ratio 3.88 [95% confidence interval (CI) 2.08–7.22]), although significant heterogeneity was evident among studies (I2 = 96.0%, Phet < 0.001). The risk of melanoma was higher for men with CLL (3.41; 95% CI 1.49–7.80) than women (2.61; 95% CI 1.13–6.01). CLL patients are at high risk of developing melanoma and the magnitude of the risk is higher than that found in other immunosuppressed populations. Our findings suggest that patients with CLL, as they are also at a higher risk of developing the more common skin cancers, would benefit from regular skin examinations.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Faculty of Medicine
Official 2016 Collection
School of Medicine Publications
 
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