Impact of lung disease on respiratory impedance in young children with cystic fibrosis

Ramsey, Kathryn A., Ranganathan, Sarath C., Gangell, Catherine L., Turkovic, Lidija, Park, Judy, Skoric, Billy, Stick, Stephen M., Sly, Peter D. and Hall, Graham L. (2015) Impact of lung disease on respiratory impedance in young children with cystic fibrosis. European Respiratory Journal, 46 6: 1672-1679. doi:10.1183/13993003.00156-2015


Author Ramsey, Kathryn A.
Ranganathan, Sarath C.
Gangell, Catherine L.
Turkovic, Lidija
Park, Judy
Skoric, Billy
Stick, Stephen M.
Sly, Peter D.
Hall, Graham L.
Title Impact of lung disease on respiratory impedance in young children with cystic fibrosis
Journal name European Respiratory Journal   Check publisher's open access policy
ISSN 1399-3003
0903-1936
Publication date 2015-12-01
Year available 2015
Sub-type Article (original research)
DOI 10.1183/13993003.00156-2015
Open Access Status Not yet assessed
Volume 46
Issue 6
Start page 1672
End page 1679
Total pages 8
Place of publication Lausanne, Switzerland
Publisher European Respiratory Society
Collection year 2016
Language eng
Abstract This study aimed to evaluate the ability of the forced oscillation technique (FOT) to detect underlying lung disease in preschool children with cystic fibrosis (CF) diagnosed following newborn screening. 184 children (aged 3–6 years) with CF underwent lung function testing on 422 occasions using the FOT to assess respiratory resistance and reactance at the time of their annual bronchoalveolar lavage collection and chest computed tomography scan. We examined associations between FOT outcomes and the presence and progression of respiratory inflammation, infection and structural lung disease. Children with CF who had pronounced respiratory disease, including free neutrophil elastase activity, infection with pro-inflammatory pathogens and structural lung abnormalities had similar FOT outcomes to those children without detectable lung disease. In addition, the progression of lung disease over 1 year was not associated with worsening FOT outcomes. We conclude that the forced oscillation technique is relatively insensitive to detect underlying lung disease in preschool children with CF. However, FOT may still be of value in improving our understanding of the physiological changes associated with early CF lung disease.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
Child Health Research Centre Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 1 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 1 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 15 Dec 2015, 00:20:09 EST by System User on behalf of Scholarly Communication and Digitisation Service