Effects of supercritical carbon dioxide processing on optical crystallinity and in vitro release of progesterone and Gelucire 44/14 solid and semi-solid dispersions

Falconer, J. R., Wen, J., Zargar-Shoshtari, S., Chen, J. J., Farid, M., Young, S. and Alany, R. G. (2013) Effects of supercritical carbon dioxide processing on optical crystallinity and in vitro release of progesterone and Gelucire 44/14 solid and semi-solid dispersions. Journal of Drug Delivery Science and Technology, 23 5: 477-483. doi:10.1016/S1773-2247(13)50069-4


Author Falconer, J. R.
Wen, J.
Zargar-Shoshtari, S.
Chen, J. J.
Farid, M.
Young, S.
Alany, R. G.
Title Effects of supercritical carbon dioxide processing on optical crystallinity and in vitro release of progesterone and Gelucire 44/14 solid and semi-solid dispersions
Journal name Journal of Drug Delivery Science and Technology   Check publisher's open access policy
ISSN 1773-2247
Publication date 2013-01-01
Sub-type Article (original research)
DOI 10.1016/S1773-2247(13)50069-4
Open Access Status Not Open Access
Volume 23
Issue 5
Start page 477
End page 483
Total pages 7
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Abstract The aim of this study was to determine the effect of supercritical carbon dioxide (SC-CO2) on the crystallinity and drug release of Gelucire 44/14-based endogenous progesterone (PGN) dispersion systems. The light scattering from PGN crystals incorporated in Gelucire 44/14 was imaged using optical microscopy. In vitro dissolution was used to determine the release kinetics of PGN, Gelucire 44/14, incorporated by a supercritical fluid (SCF) method. Release profiles were evaluated according to zero-order, first-order, Higuchi, Krosmeyer-Peppas, and dual first-order models. The dual first-order release model illustrated two distinct release rates: an initial rapid release followed by a slow diffusion of PGN from the dispersion systems. The dual first-order release model adds a new tool to the elucidation of release mechanisms from lipid and micelle-forming-based dispersion systems, where parallel processes contribute to drug release.
Keyword Factorial design experiment
Particles from gas-saturated suspensions (PGSS)
Process yield
Mathematical iteration curves
Dual first order
Transdermal Delivery
Drug
Microemulsions
Carbamazepine
Formulations
Dissolution
Excipients
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Pharmacy Publications
 
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