Head motion and Inattention/Hyperactivity share common genetic influences: implications for fMRI studies of ADHD
Head motion (HM) is a well known confound in analyses of functional MRI (fMRI) data. Neuroimaging researchers therefore typically treat HM as a nuisance covariate in their analyses. Even so, it is possible that HM shares a common genetic influence with the trait of interest. Here we investigate the extent to which this relationship is due to shared genetic factors, using HM extracted from resting-state fMRI and maternal and self report measures of Inattention and Hyperactivity-Impulsivity from the Strengths and Weaknesses of ADHD Symptoms and Normal Behaviour (SWAN) scales. Our twin design enabled us to distinguish genetic from environmental factors in the association between head movement and ADHD scales.
Our sample consisted of healthy young adult twins (N=627 (63% females) including 95 MZ and 144 DZ twin pairs, mean age 22, who had mother-reported SWAN; N=725 (58% females) including 101 MZ and 156 DZ pairs, mean age 25, with self reported SWAN). One csv file of 167 KB with comma separator.