Self-assembling lipopeptides with a potent activity against Gram-positive bacteria, including multidrug resistant strains

Azmi, Fazren, Elliott, Alysha G., Khalil, Zeinab G., Hussein, Waleed M., Kavanagh, Angela, Huang, Johnny X., Quezada, Michelle, Blaskovich, Mark A. T., Capon, Robert J., Cooper, Matthew A., Skwarczynski, Mariusz and Toth, Istvan (2015) Self-assembling lipopeptides with a potent activity against Gram-positive bacteria, including multidrug resistant strains. Nanomedicine, 10 22: 3359-3371. doi:10.2217/nnm.15.137


Author Azmi, Fazren
Elliott, Alysha G.
Khalil, Zeinab G.
Hussein, Waleed M.
Kavanagh, Angela
Huang, Johnny X.
Quezada, Michelle
Blaskovich, Mark A. T.
Capon, Robert J.
Cooper, Matthew A.
Skwarczynski, Mariusz
Toth, Istvan
Title Self-assembling lipopeptides with a potent activity against Gram-positive bacteria, including multidrug resistant strains
Journal name Nanomedicine   Check publisher's open access policy
ISSN 1743-5889
1748-6963
Publication date 2015
Sub-type Article (original research)
DOI 10.2217/nnm.15.137
Open Access Status Not Open Access
Volume 10
Issue 22
Start page 3359
End page 3371
Total pages 13
Place of publication London, United Kingdom
Publisher Future Medicine
Collection year 2016
Language eng
Formatted abstract
Aim: To explore the potential of de novo designed cyclic lipopeptides and its linear counterparts as antibacterial agents.

Materials & methods: The lipopeptides were synthesized via solid-phase peptide synthesis and the cyclization was achieved by using succinic acid linker. The antimicrobial activities of the lipopeptides were evaluated in vitro against a variety selection of Gram-negative and Gram-positive bacteria including clinical isolates of multidrug-resistant strains.

Results: The synthesized lipopeptides were able to self-assemble into nanoparticles in an aqueous environment, with three exhibiting potent antibacterial activity against Gram-positive bacteria, including clinically relevant multidrug-resistant bacteria.

Conclusion: The lead compounds have the potential to be developed as new antibacterials that are effective against Gram-positive bacteria, including multidrug-resistant isolates.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
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Created: Wed, 09 Dec 2015, 08:34:30 EST by Susan Allen on behalf of Institute for Molecular Bioscience