Independent and combined effects of physical activity and body mass index on the development of Type 2 Diabetes – a meta-analysis of 9 prospective cohort studies

Cloostermans, Laura, Wendel-Vos, Wanda, Doornbos, Gerda, Howard, Bethany, Craig, Cora Lynn, Kivimäki, Mika, Tabak, Adam G., Jefferis, Barbara J., Ronkainen, Kimmo, Brown, Wendy J., Picavet, Susan H. S. J., Ben-Shlomo, Yoav, Laukkanen, Jari Antero, Kauhanen, Jussi and Bemelmans, Wanda J. E. (2015) Independent and combined effects of physical activity and body mass index on the development of Type 2 Diabetes – a meta-analysis of 9 prospective cohort studies. International Journal of Behavioral Nutrition and Physical Activity, 12 1: 147.1-147.11. doi:10.1186/s12966-015-0304-3


Author Cloostermans, Laura
Wendel-Vos, Wanda
Doornbos, Gerda
Howard, Bethany
Craig, Cora Lynn
Kivimäki, Mika
Tabak, Adam G.
Jefferis, Barbara J.
Ronkainen, Kimmo
Brown, Wendy J.
Picavet, Susan H. S. J.
Ben-Shlomo, Yoav
Laukkanen, Jari Antero
Kauhanen, Jussi
Bemelmans, Wanda J. E.
Title Independent and combined effects of physical activity and body mass index on the development of Type 2 Diabetes – a meta-analysis of 9 prospective cohort studies
Journal name International Journal of Behavioral Nutrition and Physical Activity   Check publisher's open access policy
ISSN 1479-5868
Publication date 2015
Sub-type Article (original research)
DOI 10.1186/s12966-015-0304-3
Open Access Status DOI
Volume 12
Issue 1
Start page 147.1
End page 147.11
Total pages 11
Place of publication London, United Kingdom
Publisher BioMed Central
Collection year 2016
Language eng
Formatted abstract
Background: The aim of this harmonized meta-analysis was to examine the independent and combined effects of physical activity and BMI on the incidence of type 2 diabetes.

Methods: Our systematic literature review in 2011 identified 127 potentially relevant prospective studies of which 9 fulfilled the inclusion criteria (total N = 117,878, 56.2 % female, mean age = 50.0 years, range = 25–65 years). Measures of baseline physical activity (low, intermediate, high), BMI-category [BMI < 18.4 (underweight), 18.5–24.9 (normal weight), 25.0–29.9 (overweight), 30+ (obese)] and incident type 2 diabetes were harmonized across studies. The associations between physical activity, BMI and incident type 2 diabetes were analyzed using Cox regression with a standardized analysis protocol including adjustments for age, gender, educational level, and smoking. Hazard ratios from individual studies were combined in a random-effects meta-analysis.

Results: Mean follow-up time was 9.1 years. A total of 11,237 incident type 2 diabetes cases were recorded. In mutually adjusted models, being overweight or obese (compared with normal weight) and having low physical activity (compared with high physical activity) were associated with an increased risk of incident type 2 diabetes (hazard ratios 2.33, 95 % CI 1.95–2.78; 6.10, 95 % CI: 4.63–8.04, and 1.23, 95 % CI: 1.09–1.39, respectively). Individuals who were both obese and had low physical activity had 7.4-fold (95 % CI 3.47–15.89) increased risk of type 2 diabetes compared with normal weight, high physically active participants.

Conclusions: This harmonized meta-analysis shows the importance of maintaining a healthy weight and being physically active in diabetes prevention.
Keyword Physical activity
Body mass index
Overweight
Obesity
Meta-analysis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Human Movement and Nutrition Sciences Publications
 
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Created: Tue, 08 Dec 2015, 09:17:04 EST by Sandrine Ducrot on behalf of School of Human Movement and Nutrition Sciences