Establishing diversity in the dopaminergic system

Bodea, Gabriela O. and Blaess, Sandra (2015) Establishing diversity in the dopaminergic system. FEBS Letters (Federation of European Biochemical Socities), 589 24, Part A: 3773-3785. doi:10.1016/j.febslet.2015.09.016

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Author Bodea, Gabriela O.
Blaess, Sandra
Title Establishing diversity in the dopaminergic system
Journal name FEBS Letters (Federation of European Biochemical Socities)   Check publisher's open access policy
ISSN 0014-5793
1873-3468
Publication date 2015-12-21
Year available 2015
Sub-type Article (original research)
DOI 10.1016/j.febslet.2015.09.016
Open Access Status File (Author Post-print)
Volume 589
Issue 24, Part A
Start page 3773
End page 3785
Total pages 13
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2016
Language eng
Abstract Midbrain dopaminergic neurons (MbDNs) modulate cognitive processes, regulate voluntary movement, and encode reward prediction errors and aversive stimuli. While the degeneration of MbDNs underlies the motor defects in Parkinson’s disease, imbalances in dopamine levels are associated with neuropsychiatric disorders such as depression, schizophrenia and substance abuse. In recent years, progress has been made in understanding how MbDNs, which constitute a relatively small neuronal population in the brain, can contribute to such diverse functions and dysfunctions. In particular, important insights have been gained regarding the distinct molecular, neurochemical and network properties of MbDNs. How this diversity of MbDNs is established during brain development is only starting to be unraveled. In this review, we summarize the current knowledge on the diversity in MbDN progenitors and differentiated MbDNs in the developing rodent brain. We discuss the signaling pathways, transcription factors and transmembrane receptors that contribute to setting up these diverse MbDN subpopulations. A better insight into the processes that establish diversity in MbDNs will ultimately improve the understanding of the architecture and function of the dopaminergic system in the adult brain.
Keyword Midbrain
Progenitor
Differentiation
Migration
Axonal pathfinding
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Mater Research Institute-UQ (MRI-UQ)
Queensland Brain Institute Publications
Official 2016 Collection
 
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Created: Mon, 07 Dec 2015, 14:29:06 EST by Susan Day on behalf of Queensland Brain Institute