The influence of age and sex on genetic associations with adult body size and shape: a large-scale genome-wide interaction study

Winkler, Thomas W., Justice, Anne E., Graff, Mariaelisa, Barata, Llilda, Feitosa, Mary F., Chu, Su, Czajkowski, Jacek, Esko, Tonu, Fall, Tove, Kilpelainen, Tuomas O., Lu, Yingchang, Magi, Reedik, Mihailov, Evelin, Pers, Tune H., Rueeger, Sina, Teumer, Alexander, Ehret, Georg B., Ferreira, Teresa, Heard-Costa, Nancy L., Karjalainen, Juha, Lagou, Vasiliki, Mahajan, Anubha, Neinast, Michael D., Prokopenko, Inga, Simino, Jeannette, Teslovich, Tanya M., Jansen, Rick, Westra, Harm-Jan, White, Charles C., Absher, Devin, Ahluwalia, Tarunveer S., Ahmad, Shafqat, Albrecht, Eva, Alves, Alexessander Couto, Bragg-Gresham, Jennifer L., de Craen, Anton J. M., Bis, Joshua C., Bonnefond, Amelie, Boucher, Gabrielle, Cadby, Gemma, Cheng, Yu-Ching, Chiang, Charleston W. K., Delgado, Graciela, Demirkan, Ayse, Dueker, Nicole, Eklund, Niina, Eiriksdottir, Gudny, Eriksson, Joel, Feenstra, Bjarke, Fischer, Krista, Frau, Francesca, Galesloot, Tessel E., Geller, Frank, Goel, Anuj, Gorski, Mathias, Grammer, Tanja B., Gustafsson, Stefan, Haitjema, Saskia, Hottenga, Jouke-Jan, Huffman, Jennifer E., Jackson, Anne U., Jacobs, Kevin B., Johansson, Asa, Kaakinen, Marika, Kleber, Marcus E., Lahti, Jari, Leach, Irene Mateo, Lehne, Benjamin, Liu, Youfang, Lo, Ken Sin, Lorentzon, Mattias, Luan, Jian'an, Madden, Pamela A. F., Mangino, Massimo, McKnight, Barbara, Medina-Gomez, Carolina, Monda, Keri L., Montasser, May E., Mueller, Gabriele, Mueller-Nurasyid, Martina, Nolte, Ilja M., Panoutsopoulou, Kalliope, Pascoe, Laura, Paternoster, Lavinia, Rayner, Nigel W., Renstrom, Frida, Rizzi, Federica, Rose, Lynda M., Ryan, Kathy A., Salo, Perttu, Sanna, Serena, Scharnagl, Hubert, Shi, Jianxin, Smith, Albert Vernon, Southam, Lorraine, Stancakova, Alena, Steinthorsdottir, Valgerdur, Strawbridge, Rona J., Sung, Yun Ju, Tachmazidou, Ioanna, Tanaka, Toshiko, Thorleifsson, Gudmar, Trompet, Stella, Pervjakova, Natalia, Tyrer, Jonathan P., Vandenput, Liesbeth, van der Laan, Sander W., van der Velde, Nathalie, van Setten, Jessica, van Vliet-Ostaptchouk, Jana V., Verweij, Niek, Vlachopoulou, Efthymia, Waite, Lindsay L., Wang, Sophie R., Wang, Zhaoming, Wild, Sarah H., Willenborg, Christina, Wilson, James F., Wong, Andrew, Yang, Jian, Yengo, Loic, Yerges-Armstrong, Laura M., Yu, Lei, Zhang, Weihua, Zhao, Jing Hua, Andersson, Ehm A., Bakker, Stephan J. L., Baldassarre, Damiano, Banasik, Karina, Barcella, Matteo, Barlassina, Cristina, Bellis, Claire, Benaglio, Paola, Blangero, John, Blueher, Matthias, Bonnet, Fabrice, Bonnycastle, Lori L., Boyd, Heather A., Bruinenberg, Marcel, Buchman, Aron S., Campbell, Harry, Chen, Yii-Der Ida, Chines, Peter S., Claudi-Boehm, Simone, Cole, John, Collins, Francis S., de Geus, Eco J. C., de Groot, Lisette C. P. G. M., Dimitriou, Maria, Duan, Jubao, Enroth, Stefan, Eury, Elodie, Farmaki, Aliki-Eleni, Forouhi, Nita G., Friedrich, Nele, Gejman, Pablo V., Gigante, Bruna, Glorioso, Nicola, Go, Alan S., Gottesman, Omri, Graessler, Juergen, Grallert, Harald, Grarup, Niels, Gu, Yu-Mei, Broer, Linda, Ham, Annelies C., Hansen, Torben, Harris, Tamara B., Hartman, Catharina A., Hassinen, Maija, Hastie, Nicholas, Hattersley, Andrew T., Heath, Andrew C., Henders, Anjali K., Hernandez, Dena, Hillege, Hans, Holmen, Oddgeir, Hovingh, Kees G., Hui, Jennie, Husemoen, Lise L., Hutri-Kahonen, Nina, Hysi, Pirro G., Illig, Thomas, De Jager, Philip L., Jalilzadeh, Shapour, Jorgensen, Torben, Jukema, J. Wouter, Juonala, Markus, Kanoni, Stavroula, Karaleftheri, Maria, Khaw, Kay Tee, Kinnunen, Leena, Kittner, Steven J., Koenig, Wolfgang, Kolcic, Ivana, Kovacs, Peter, Krarup, Nikolaj T., Kratzer, Wolfgang, Krueger, Janine, Kuh, Diana, Kumari, Meena, Kyriakou, Theodosios, Langenberg, Claudia, Lannfelt, Lars, Lanzani, Chiara, Lotay, Vaneet, Launer, Lenore J., Leander, Karin, Lindstrom, Jaana, Linneberg, Allan, Liu, Yan-Ping, Lobbens, Stephane, Luben, Robert, Lyssenko, Valeriya, Mannisto, Satu, Magnusson, Patrik K., McArdle, Wendy L., Menni, Cristina, Merger, Sigrun, Milani, Lili, Montgomery, Grant W., Morris, Andrew P., Narisu, Narisu, Nelis, Mari, Ong, Ken K., Palotie, Aarno, Perusse, Louis, Pichler, Irene, Pilia, Maria G., Pouta, Anneli, Rheinberger, Myriam, Ribel-Madsen, Rasmus, Richards, Marcus, Rice, Kenneth M., Rice, Treva K., Rivolta, Carlo, Salomaa, Veikko, Sanders, Alan R., Sarzynski, Mark A., Scholtens, Salome, Scott, Robert A., Scott, William R., Sebert, Sylvain, Sengupta, Sebanti, Sennblad, Bengt, Seufferlein, Thomas, Silveira, Angela, Slagboom, P. Eline, Smit, Jan H., Sparso, Thomas H., Stirrups, Kathleen, Stolk, Ronald P., Stringham, Heather M., Swertz, Morris A., Swift, Amy J., Syvanen, Ann-Christine, Tan, Sian-Tsung, Thorand, Barbara, Toenjes, Anke, Tremblay, Angelo, Tsafantakis, Emmanouil, van der Most, Peter J., Voelker, Uwe, Vohl, Marie-Claude, Vonk, Judith M., Waldenberger, Melanie, Walker, Ryan W., Wennauer, Roman, Widen, Elisabeth, Willemsen, Gonneke, Wilsgaard, Tom, Wright, Alan F., Zillikens, M. Carola, van Dijk, Suzanne C., van Schoor, Natasja M., Asselbergs, Folkert W., de Bakker, Paul I. W., Beckmann, Jacques S., Beilby, John, Bennett, David A., Bergman, Richard N., Bergmann, Sven, Boeger, Carsten A., Boehm, Bernhard O., Boerwinkle, Eric, Boomsma, Dorret I., Bornstein, Stefan R., Bottinger, Erwin P., Bouchard, Claude, Chambers, John C., Chanock, Stephen J., Chasman, Daniel I., Cucca, Francesco, Cusi, Daniele, Dedoussis, George, Erdmann, Jeanette, Eriksson, Johan G., Evans, Denis A., de Faire, Ulf, Farrall, Martin, Ferrucci, Luigi, Ford, Ian, Franke, Lude, Franks, Paul W., Froguel, Philippe, Gansevoort, Ron T., Gieger, Christian, Gronberg, Henrik, Gudnason, Vilmundur, Gyllensten, Ulf, Hall, Per, Hamsten, Anders, van der Harst, Pim, Hayward, Caroline, Heliovaara, Markku, Hengstenberg, Christian, Hicks, Andrew A., Hingorani, Aroon, Hofman, Albert, Hu, Frank, Huikuri, Heikki V., Hveem, Kristian, James, Alan L., Jordan, Joanne M., Jula, Antti, Kaehoenen, Mika, Kajantie, Eero, Kathiresan, Sekar, Kiemeney, Lambertus A. L. M., Kivimaki, Mika, Knekt, Paul B., Koistinen, Heikki A., Kooner, Jaspal S., Koskinen, Seppo, Kuusisto, Johanna, Maerz, Winfried, Martin, Nicholas G., Laakso, Markku, Lakka, Timo A., Lehtimaki, Terho, Lettre, Guillaume, Levinson, Douglas F., Lind, Lars, Lokki, Marja-Liisa, Mantyselka, Pekka, Melbye, Mads, Metspalu, Andres, Mitchell, Braxton D., Moll, Frans L., Murray, Jeffrey C., Musk, Arthur W., Nieminen, Markku S., Njolstad, Inger, Ohlsson, Claes, Oldehinkel, Albertine J., Oostra, Ben A., Palmer, Lyle J., Pankow, James S., Pasterkamp, Gerard, Pedersen, Nancy L., Pedersen, Oluf, Penninx, Brenda W., Perola, Markus, Peters, Annette, Polasek, Ozren, Pramstaller, Peter P., Psaty, Bruce M., Qi, Lu, Quertermous, Thomas, Raitakari, Olli T., Rankinen, Tuomo, Rauramaa, Rainer, Ridker, Paul M., Rioux, John D., Rivadeneira, Fernando, Rotter, Jerome I., Rudan, Igor, den Ruijter, Hester M., Saltevo, Juha, Sattar, Naveed, Schunkert, Heribert, Schwarz, Peter E. H., Shuldiner, Alan R., Sinisalo, Juha, Snieder, Harold, Sorensen, Thorkild I. A., Spector, Tim D., Staessen, Jan A., Stefania, Bandinelli, Thorsteinsdottir, Unnur, Stumvoll, Michael, Tardif, Jean-Claude, Tremoli, Elena, Tuomilehto, Jaakko, Uitterlinden, Andre G., Uusitupa, Matti, Verbeek, Andre L. M., Vermeulen, Sita H., Viikari, Jorma S., Vitart, Veronique, Voelzke, Henry, Vollenweider, Peter, Waeber, Gerard, Walker, Mark, Wallaschofski, Henri, Wareham, Nicholas J., Watkins, Hugh, Zeggini, Eleftheria, Chakravarti, Aravinda, Clegg, Deborah J., Cupples, L. Adrienne, Gordon-Larsen, Penny, Jaquish, Cashell E., Rao, D. C., Abecasis, Goncalo R., Assimes, Themistocles L., Barroso, Ines, Berndt, Sonja I., Boehnke, Michael, Deloukas, Panos, Fox, Caroline S., Groop, Leif C., Hunter, David J., Ingelsson, Erik, Kaplan, Robert C., McCarthy, Mark I., Mohlke, Karen L., O'Connell, Jeffrey R., Schlessinger, David, Strachan, David P., Stefansson, Kari, van Duijn, Cornelia M., Hirschhorn, Joel N., Lindgren, Cecilia M., Heid, Iris M., North, Kari E., Borecki, Ingrid B., Kutalik, Zoltan and Loos, Ruth J. F. (2015) The influence of age and sex on genetic associations with adult body size and shape: a large-scale genome-wide interaction study. PL o S Genetics, 11 10: 1-42. doi:10.1371/journal.pgen.1005378


Author Winkler, Thomas W.
Justice, Anne E.
Graff, Mariaelisa
Barata, Llilda
Feitosa, Mary F.
Chu, Su
Czajkowski, Jacek
Esko, Tonu
Fall, Tove
Kilpelainen, Tuomas O.
Lu, Yingchang
Magi, Reedik
Mihailov, Evelin
Pers, Tune H.
Rueeger, Sina
Teumer, Alexander
Ehret, Georg B.
Ferreira, Teresa
Heard-Costa, Nancy L.
Karjalainen, Juha
Lagou, Vasiliki
Mahajan, Anubha
Neinast, Michael D.
Prokopenko, Inga
Simino, Jeannette
Teslovich, Tanya M.
Jansen, Rick
Westra, Harm-Jan
White, Charles C.
Absher, Devin
Ahluwalia, Tarunveer S.
Ahmad, Shafqat
Albrecht, Eva
Alves, Alexessander Couto
Bragg-Gresham, Jennifer L.
de Craen, Anton J. M.
Bis, Joshua C.
Bonnefond, Amelie
Boucher, Gabrielle
Cadby, Gemma
Cheng, Yu-Ching
Chiang, Charleston W. K.
Delgado, Graciela
Demirkan, Ayse
Dueker, Nicole
Eklund, Niina
Eiriksdottir, Gudny
Eriksson, Joel
Feenstra, Bjarke
Fischer, Krista
Frau, Francesca
Galesloot, Tessel E.
Geller, Frank
Goel, Anuj
Gorski, Mathias
Grammer, Tanja B.
Gustafsson, Stefan
Haitjema, Saskia
Hottenga, Jouke-Jan
Huffman, Jennifer E.
Jackson, Anne U.
Jacobs, Kevin B.
Johansson, Asa
Kaakinen, Marika
Kleber, Marcus E.
Lahti, Jari
Leach, Irene Mateo
Lehne, Benjamin
Liu, Youfang
Lo, Ken Sin
Lorentzon, Mattias
Luan, Jian'an
Madden, Pamela A. F.
Mangino, Massimo
McKnight, Barbara
Medina-Gomez, Carolina
Monda, Keri L.
Montasser, May E.
Mueller, Gabriele
Mueller-Nurasyid, Martina
Nolte, Ilja M.
Panoutsopoulou, Kalliope
Pascoe, Laura
Paternoster, Lavinia
Rayner, Nigel W.
Renstrom, Frida
Rizzi, Federica
Rose, Lynda M.
Ryan, Kathy A.
Salo, Perttu
Sanna, Serena
Scharnagl, Hubert
Shi, Jianxin
Smith, Albert Vernon
Southam, Lorraine
Stancakova, Alena
Steinthorsdottir, Valgerdur
Strawbridge, Rona J.
Sung, Yun Ju
Tachmazidou, Ioanna
Tanaka, Toshiko
Thorleifsson, Gudmar
Trompet, Stella
Pervjakova, Natalia
Tyrer, Jonathan P.
Vandenput, Liesbeth
van der Laan, Sander W.
van der Velde, Nathalie
van Setten, Jessica
van Vliet-Ostaptchouk, Jana V.
Verweij, Niek
Vlachopoulou, Efthymia
Waite, Lindsay L.
Wang, Sophie R.
Wang, Zhaoming
Wild, Sarah H.
Willenborg, Christina
Wilson, James F.
Wong, Andrew
Yang, Jian
Yengo, Loic
Yerges-Armstrong, Laura M.
Yu, Lei
Zhang, Weihua
Zhao, Jing Hua
Andersson, Ehm A.
Bakker, Stephan J. L.
Baldassarre, Damiano
Banasik, Karina
Barcella, Matteo
Barlassina, Cristina
Bellis, Claire
Benaglio, Paola
Blangero, John
Blueher, Matthias
Bonnet, Fabrice
Bonnycastle, Lori L.
Boyd, Heather A.
Bruinenberg, Marcel
Buchman, Aron S.
Campbell, Harry
Chen, Yii-Der Ida
Chines, Peter S.
Claudi-Boehm, Simone
Cole, John
Collins, Francis S.
de Geus, Eco J. C.
de Groot, Lisette C. P. G. M.
Dimitriou, Maria
Duan, Jubao
Enroth, Stefan
Eury, Elodie
Farmaki, Aliki-Eleni
Forouhi, Nita G.
Friedrich, Nele
Gejman, Pablo V.
Gigante, Bruna
Glorioso, Nicola
Go, Alan S.
Gottesman, Omri
Graessler, Juergen
Grallert, Harald
Grarup, Niels
Gu, Yu-Mei
Broer, Linda
Ham, Annelies C.
Hansen, Torben
Harris, Tamara B.
Hartman, Catharina A.
Hassinen, Maija
Hastie, Nicholas
Hattersley, Andrew T.
Heath, Andrew C.
Henders, Anjali K.
Hernandez, Dena
Hillege, Hans
Holmen, Oddgeir
Hovingh, Kees G.
Hui, Jennie
Husemoen, Lise L.
Hutri-Kahonen, Nina
Hysi, Pirro G.
Illig, Thomas
De Jager, Philip L.
Jalilzadeh, Shapour
Jorgensen, Torben
Jukema, J. Wouter
Juonala, Markus
Kanoni, Stavroula
Karaleftheri, Maria
Khaw, Kay Tee
Kinnunen, Leena
Kittner, Steven J.
Koenig, Wolfgang
Kolcic, Ivana
Kovacs, Peter
Krarup, Nikolaj T.
Kratzer, Wolfgang
Krueger, Janine
Kuh, Diana
Kumari, Meena
Kyriakou, Theodosios
Langenberg, Claudia
Lannfelt, Lars
Lanzani, Chiara
Lotay, Vaneet
Launer, Lenore J.
Leander, Karin
Lindstrom, Jaana
Linneberg, Allan
Liu, Yan-Ping
Lobbens, Stephane
Luben, Robert
Lyssenko, Valeriya
Mannisto, Satu
Magnusson, Patrik K.
McArdle, Wendy L.
Menni, Cristina
Merger, Sigrun
Milani, Lili
Montgomery, Grant W.
Morris, Andrew P.
Narisu, Narisu
Nelis, Mari
Ong, Ken K.
Palotie, Aarno
Perusse, Louis
Pichler, Irene
Pilia, Maria G.
Pouta, Anneli
Rheinberger, Myriam
Ribel-Madsen, Rasmus
Richards, Marcus
Rice, Kenneth M.
Rice, Treva K.
Rivolta, Carlo
Salomaa, Veikko
Sanders, Alan R.
Sarzynski, Mark A.
Scholtens, Salome
Scott, Robert A.
Scott, William R.
Sebert, Sylvain
Sengupta, Sebanti
Sennblad, Bengt
Seufferlein, Thomas
Silveira, Angela
Slagboom, P. Eline
Smit, Jan H.
Sparso, Thomas H.
Stirrups, Kathleen
Stolk, Ronald P.
Stringham, Heather M.
Swertz, Morris A.
Swift, Amy J.
Syvanen, Ann-Christine
Tan, Sian-Tsung
Thorand, Barbara
Toenjes, Anke
Tremblay, Angelo
Tsafantakis, Emmanouil
van der Most, Peter J.
Voelker, Uwe
Vohl, Marie-Claude
Vonk, Judith M.
Waldenberger, Melanie
Walker, Ryan W.
Wennauer, Roman
Widen, Elisabeth
Willemsen, Gonneke
Wilsgaard, Tom
Wright, Alan F.
Zillikens, M. Carola
van Dijk, Suzanne C.
van Schoor, Natasja M.
Asselbergs, Folkert W.
de Bakker, Paul I. W.
Beckmann, Jacques S.
Beilby, John
Bennett, David A.
Bergman, Richard N.
Bergmann, Sven
Boeger, Carsten A.
Boehm, Bernhard O.
Boerwinkle, Eric
Boomsma, Dorret I.
Bornstein, Stefan R.
Bottinger, Erwin P.
Bouchard, Claude
Chambers, John C.
Chanock, Stephen J.
Chasman, Daniel I.
Cucca, Francesco
Cusi, Daniele
Dedoussis, George
Erdmann, Jeanette
Eriksson, Johan G.
Evans, Denis A.
de Faire, Ulf
Farrall, Martin
Ferrucci, Luigi
Ford, Ian
Franke, Lude
Franks, Paul W.
Froguel, Philippe
Gansevoort, Ron T.
Gieger, Christian
Gronberg, Henrik
Gudnason, Vilmundur
Gyllensten, Ulf
Hall, Per
Hamsten, Anders
van der Harst, Pim
Hayward, Caroline
Heliovaara, Markku
Hengstenberg, Christian
Hicks, Andrew A.
Hingorani, Aroon
Hofman, Albert
Hu, Frank
Huikuri, Heikki V.
Hveem, Kristian
James, Alan L.
Jordan, Joanne M.
Jula, Antti
Kaehoenen, Mika
Kajantie, Eero
Kathiresan, Sekar
Kiemeney, Lambertus A. L. M.
Kivimaki, Mika
Knekt, Paul B.
Koistinen, Heikki A.
Kooner, Jaspal S.
Koskinen, Seppo
Kuusisto, Johanna
Maerz, Winfried
Martin, Nicholas G.
Laakso, Markku
Lakka, Timo A.
Lehtimaki, Terho
Lettre, Guillaume
Levinson, Douglas F.
Lind, Lars
Lokki, Marja-Liisa
Mantyselka, Pekka
Melbye, Mads
Metspalu, Andres
Mitchell, Braxton D.
Moll, Frans L.
Murray, Jeffrey C.
Musk, Arthur W.
Nieminen, Markku S.
Njolstad, Inger
Ohlsson, Claes
Oldehinkel, Albertine J.
Oostra, Ben A.
Palmer, Lyle J.
Pankow, James S.
Pasterkamp, Gerard
Pedersen, Nancy L.
Pedersen, Oluf
Penninx, Brenda W.
Perola, Markus
Peters, Annette
Polasek, Ozren
Pramstaller, Peter P.
Psaty, Bruce M.
Qi, Lu
Quertermous, Thomas
Raitakari, Olli T.
Rankinen, Tuomo
Rauramaa, Rainer
Ridker, Paul M.
Rioux, John D.
Rivadeneira, Fernando
Rotter, Jerome I.
Rudan, Igor
den Ruijter, Hester M.
Saltevo, Juha
Sattar, Naveed
Schunkert, Heribert
Schwarz, Peter E. H.
Shuldiner, Alan R.
Sinisalo, Juha
Snieder, Harold
Sorensen, Thorkild I. A.
Spector, Tim D.
Staessen, Jan A.
Stefania, Bandinelli
Thorsteinsdottir, Unnur
Stumvoll, Michael
Tardif, Jean-Claude
Tremoli, Elena
Tuomilehto, Jaakko
Uitterlinden, Andre G.
Uusitupa, Matti
Verbeek, Andre L. M.
Vermeulen, Sita H.
Viikari, Jorma S.
Vitart, Veronique
Voelzke, Henry
Vollenweider, Peter
Waeber, Gerard
Walker, Mark
Wallaschofski, Henri
Wareham, Nicholas J.
Watkins, Hugh
Zeggini, Eleftheria
Chakravarti, Aravinda
Clegg, Deborah J.
Cupples, L. Adrienne
Gordon-Larsen, Penny
Jaquish, Cashell E.
Rao, D. C.
Abecasis, Goncalo R.
Assimes, Themistocles L.
Barroso, Ines
Berndt, Sonja I.
Boehnke, Michael
Deloukas, Panos
Fox, Caroline S.
Groop, Leif C.
Hunter, David J.
Ingelsson, Erik
Kaplan, Robert C.
McCarthy, Mark I.
Mohlke, Karen L.
O'Connell, Jeffrey R.
Schlessinger, David
Strachan, David P.
Stefansson, Kari
van Duijn, Cornelia M.
Hirschhorn, Joel N.
Lindgren, Cecilia M.
Heid, Iris M.
North, Kari E.
Borecki, Ingrid B.
Kutalik, Zoltan
Loos, Ruth J. F.
Title The influence of age and sex on genetic associations with adult body size and shape: a large-scale genome-wide interaction study
Journal name PL o S Genetics   Check publisher's open access policy
ISSN 1553-7404
1553-7390
Publication date 2015-10
Sub-type Article (original research)
DOI 10.1371/journal.pgen.1005378
Open Access Status DOI
Volume 11
Issue 10
Start page 1
End page 42
Total pages 42
Place of publication San Francisco, CA United States
Publisher Public Library of Science
Collection year 2016
Language eng
Formatted abstract
Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age- and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to ~2.8M SNPs with BMI and WHRadjBMI in four strata (men 50y, men >50y, women 50y, women >50y) and summary statistics were combined in stratum-specific meta-analyses. We then screened for variants that showed age-specific effects (G x AGE), sex-specific effects (G x SEX) or age-specific effects that differed between men and women (G x AGE x SEX). For BMI, we identified 15 loci (11 previously established for main effects, four novel) that showed significant (FDR<5%) age-specific effects, of which 11 had larger effects in younger (<50y) than in older adults (50y). No sex-dependent effects were identified for BMI. For WHRadjBMI, we identified 44 loci (27 previously established for main effects, 17 novel) with sex-specific effects, of which 28 showed larger effects in women than in men, five showed larger effects in men than in women, and 11 showed opposite effects between sexes. No age-dependent effects were identified for WHRadjBMI. This is the first genome-wide interaction meta-analysis to report convincing evidence of age-dependent genetic effects on BMI. In addition, we confirm the sex-specificity of genetic effects on WHRadjBMI. These results may provide further insights into the biology that underlies weight change with age or the sexually dimorphism of body shape.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2016 Collection
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 13 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 15 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 06 Dec 2015, 00:26:47 EST by System User on behalf of Scholarly Communication and Digitisation Service