Molecular characterization of the multidrug resistant escherichia coli ST131 clone

Schembri, Mark A., Ben Zakour, Nouri L., Minh-Duy Phan, Forde, Brian M., Stanton-Cook, Mitchell and Beatson, Scott A. (2015) Molecular characterization of the multidrug resistant escherichia coli ST131 clone. Pathogens, 4 3: 422-430. doi:10.3390/pathogens4030422


Author Schembri, Mark A.
Ben Zakour, Nouri L.
Minh-Duy Phan
Forde, Brian M.
Stanton-Cook, Mitchell
Beatson, Scott A.
Title Molecular characterization of the multidrug resistant escherichia coli ST131 clone
Journal name Pathogens   Check publisher's open access policy
ISSN 2076-0817
Publication date 2015-09
Sub-type Critical review of research, literature review, critical commentary
DOI 10.3390/pathogens4030422
Open Access Status DOI
Volume 4
Issue 3
Start page 422
End page 430
Total pages 9
Place of publication MDPIAG
Publisher Basel, Switzerland
Collection year 2016
Language eng
Formatted abstract
Escherichia coli ST131 is a recently emerged and globally disseminated multidrug resistant clone associated with urinary tract and bloodstream infections in both community and clinical settings. The most common group of ST131 strains are defined by resistance to fluoroquinolones and possession of the type 1 fimbriae fimH30 allele. Here we provide an update on our recent work describing the globally epidemiology of ST131. We review the phylogeny of ST131 based on whole genome sequence data and highlight the important role of recombination in the evolution of this clonal lineage. We also summarize our findings on the virulence of the ST131 reference strain EC958, and highlight the use of transposon directed insertion-site sequencing to define genes associated with serum resistance and essential features of its large antibiotic resistance plasmid pEC958.
Keyword Uropathogenic Escherichia coli
St131
Urinary tract
FimH
Virulence
Genomics
TraDIS
Plasmid
Antibiotic resistance
Strain
Emergence
Sequence
Genome
Epidemiology
Infection
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2016 Collection
School of Chemistry and Molecular Biosciences
 
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