Evolving systemic targeted therapy strategies in uveal melanoma and implications for ophthalmic management: a review

Goh, Amanda Y. L. and Layton, Christopher J. (2016) Evolving systemic targeted therapy strategies in uveal melanoma and implications for ophthalmic management: a review. Clinical and Experimental Ophthalmology, 44 6: 509-519. doi:10.1111/ceo.12688


Author Goh, Amanda Y. L.
Layton, Christopher J.
Title Evolving systemic targeted therapy strategies in uveal melanoma and implications for ophthalmic management: a review
Journal name Clinical and Experimental Ophthalmology   Check publisher's open access policy
ISSN 1442-6404
1442-9071
Publication date 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/ceo.12688
Open Access Status Not Open Access
Volume 44
Issue 6
Start page 509
End page 519
Total pages 11
Place of publication Richmond, VIC, Australia
Publisher Wiley-Blackwell
Collection year 2017
Language eng
Abstract Uveal melanoma (UM) is the most common primary ocular tumour in adults. Despite good local control of the primary tumour with current methods, survival after the development of metastasis has remained poor over the last 30 years. After cutaneous melanoma (CM), UM is the most common type of melanoma, and an ongoing debate exists regarding whether these conditions should be considered separate entities, particularly in the context of targeted therapy, where many of the initial trials for metastatic CM patients excluded metastatic UM (MUM). This paper will review the recent and ongoing investigations designed to validate systemic targeted therapy and immunotherapy in MUM patients, and suggests ways in which these developments may affect management of UM by ophthalmologists in the near future.
Keyword Uveal melanoma
Immunotherapy
Gene Therapy
Chemotherapy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
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Created: Tue, 01 Dec 2015, 06:26:29 EST by Christopher James Layton on behalf of Surgery - Greenslopes Private Hospital