Normal values for pancreatic stone protein in different age groups

Schlapbach, Luregn J., Giannoni, Eric, Wellmann, Sven, Stocker, Martin, Ammann, Roland A. and Graf, Rolf (2015) Normal values for pancreatic stone protein in different age groups. BMC Anesthesiology, 15 1: 1-6. doi:10.1186/s12871-015-0149-y


Author Schlapbach, Luregn J.
Giannoni, Eric
Wellmann, Sven
Stocker, Martin
Ammann, Roland A.
Graf, Rolf
Title Normal values for pancreatic stone protein in different age groups
Journal name BMC Anesthesiology   Check publisher's open access policy
ISSN 1471-2253
Publication date 2015-11-20
Year available 2015
Sub-type Article (original research)
DOI 10.1186/s12871-015-0149-y
Open Access Status DOI
Volume 15
Issue 1
Start page 1
End page 6
Total pages 6
Place of publication London, United Kingdom
Publisher BioMed Central
Collection year 2016
Language eng
Formatted abstract
Background
Pancreatic stone protein (PSP) has been identified as a promising sepsis marker in adults, children and neonates. However, data on population-based reference values are lacking. This study aimed to establish age-specific reference values for PSP.

Methods
PSP was determined using a specific ELISA. PSP serum concentrations were determined in 372 healthy subjects including 217 neonates, 94 infants and children up to 16 years, and 61 adults. The adjacent categories method was used to determine which age categories had significantly different PSP concentrations.

Results
PSP circulating levels were not gender-dependent and ranged from 1.0 to 99.4 ng/ml with a median of 9.2 ng/ml. PSP increased significantly between the age categories, from a median of 2.6 ng/ml in very preterm newborns, to 6.3 ng/ml in term newborns, to 16.1 ng/ml in older children (p < 0.001). PSP levels were higher on postnatal day three compared to levels measured immediately post delivery (p < 0.001). Paired umbilical artery and umbilical vein samples were strongly correlated (p < 0.001). Simultaneously obtained capillary heel-prick versus venous samples showed a good level of agreement for PSP (Rho 0.89, bias 19 %).

Conclusions
This study provides age-specific normal values that may be used to define cut-offs for future trials on PSP. We demonstrate an age-dependent increase of PSP from birth to childhood.
Keyword Intensive care unit
Pancreatic stone protein
Sepsis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Mater Research Institute-UQ (MRI-UQ)
Official 2016 Collection
School of Medicine Publications
 
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