TAp63 regulates oncogenic miR-155 to mediate migration and tumour growth

Mattiske, Sam, Ho, Kristen, Noll, Jacqueline E., Neilsen, Paul M., Callen, David F. and Suetani, Rachel J. (2013) TAp63 regulates oncogenic miR-155 to mediate migration and tumour growth. OncoTarget, 4 11: 1894-1903.

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Author Mattiske, Sam
Ho, Kristen
Noll, Jacqueline E.
Neilsen, Paul M.
Callen, David F.
Suetani, Rachel J.
Title TAp63 regulates oncogenic miR-155 to mediate migration and tumour growth
Journal name OncoTarget   Check publisher's open access policy
ISSN 1949-2553
Publication date 2013-08-31
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 4
Issue 11
Start page 1894
End page 1903
Total pages 10
Place of publication Albany, NY, United States
Publisher Impact Journals LLC
Language eng
Formatted abstract
miR-155 is an oncogenic microRNA which is upregulated in many solid cancers. The targets of miR-155 are well established, with over 100 confirmed mRNA targets. However, the regulation of miR-155 and the basis of its upregulation in cancer is not well understood. We have previously shown that miR-155 is regulated by p63, and here we investigate the role of the major p63 isoforms TAp63 and ΔNp63 in this regulation. When the TAp63 isoform was knocked down, or exogenously overexpressed, miR-155 levels were elevated in response to TAp63 knockdown or reduced in response to TAp63 overexpression. The ΔNp63 isoform is shown to directly bind to the p63 response element on the miR-155 host gene, and this binding is enriched when TAp63 is knocked down. This could indicate that TAp63 prevents ?Np63 from binding to the miR-155 host gene. The knockdown of TAp63, and the subsequent elevation of miR-155, enhances migration and tumour growth similar to that seen when directly overexpressing miR-155. The migratory phenotype is abrogated when miR-155 is inhibited, indicating that miR-155 is responsible for the phenotypic effect of TAp63 knockdown.
Keyword ΔNp63
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
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Created: Mon, 30 Nov 2015, 11:45:42 EST by Rachel Suetani on behalf of Queensland Brain Institute